Research ArticleCell Biology

CD13 tethers the IQGAP1-ARF6-EFA6 complex to the plasma membrane to promote ARF6 activation, β1 integrin recycling, and cell migration

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Science Signaling  30 Apr 2019:
Vol. 12, Issue 579, eaav5938
DOI: 10.1126/scisignal.aav5938

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Recycle and go forth!

Cell migration and motility are critical to embryonic development, immunity, and tissue repair, but uncontrolled migration can lead to disease. Cell migration is mediated in large part through mechanical signals from the cell surface, such as those mediated through the cyclic trafficking of integrins in response to contact with the extracellular matrix (ECM). Ghosh et al. found that the presence of the multifunctional peptidase CD13 at the cell surface facilitated the recruitment of a complex of proteins to the leading edge of migrating cells that promoted β1 integrin recycling to the surface, rather than its degradation, after ECM contact-induced internalization, which enhanced cell migration. These findings expand our understanding of cell migration mechanisms and identify possible targets to therapeutically control it.

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