14 May 2019
Vol 12, Issue 581

About The Cover

Cover image expansion

Online Cover This week features a Research Article that describes the transcriptional regulators responsible for determining distinct macrophage states. Single-cell analyses of mRNA and proteins characterized the pro- and anti-inflammatory macrophage states induced by the microbial product LPS and the free fatty acid palmitate, both of which act through the receptor TLR4. The image shows immunofluorescence detection of various pro- and anti-inflammatory factors in primary human macrophages. [Image: Fischer et al./Science Signaling]