Signals trigger state-specific transcriptional programs to support diversity and homeostasis in immune cells

Cornelius Fischer; Maria Metsger; Sophia Bauch; Ramon Vidal; Michael Böttcher; Phillip Grote; Magdalena Kliem; Sascha Sauer

doi:10.1126/scisignal.aao5820

Research ArticleImmunology

Signals trigger state-specific transcriptional programs to support diversity and homeostasis in immune cells

Cornelius Fischer¹,²,³,*,
Maria Metsger¹,²,³,⁴,*,
Sophia Bauch¹,²,
Ramon Vidal¹,
Michael Böttcher²,
Phillip Grote²,⁵,
Magdalena Kliem¹,², and
Sascha Sauer¹,²,⁶,†

¹Laboratory of Functional Genomics, Nutrigenomics and Systems Biology, Scientific Genomics Platforms, Max Delbrück Center for Molecular Medicine (BIMSB/BIH), 13092 Berlin, Germany.
²Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.
³Department of Biology, Chemistry, and Pharmacy, Free University of Berlin, 14195 Berlin, Germany.
⁴Central European Institute of Technology, Masaryk University, 62500 Brno, Czech Republic.
⁵Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University, 60590 Frankfurt am Main, Germany.
⁶CU Systems Medicine, University of Würzburg, 97080 Würzburg, Germany.

↵†Corresponding author. Email: sascha.sauer{at}mdc-berlin.de

↵* These authors contributed equally to this work.

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Science Signaling 14 May 2019:
Vol. 12, Issue 581, eaao5820
DOI: 10.1126/scisignal.aao5820

Cornelius Fischer

Laboratory of Functional Genomics, Nutrigenomics and Systems Biology, Scientific Genomics Platforms, Max Delbrück Center for Molecular Medicine (BIMSB/BIH), 13092 Berlin, Germany.Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.Department of Biology, Chemistry, and Pharmacy, Free University of Berlin, 14195 Berlin, Germany.

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Maria Metsger

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Sophia Bauch

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Ramon Vidal

Laboratory of Functional Genomics, Nutrigenomics and Systems Biology, Scientific Genomics Platforms, Max Delbrück Center for Molecular Medicine (BIMSB/BIH), 13092 Berlin, Germany.

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Michael Böttcher

Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.

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Phillip Grote

Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University, 60590 Frankfurt am Main, Germany.

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Magdalena Kliem

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Sascha Sauer

Laboratory of Functional Genomics, Nutrigenomics and Systems Biology, Scientific Genomics Platforms, Max Delbrück Center for Molecular Medicine (BIMSB/BIH), 13092 Berlin, Germany.Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.CU Systems Medicine, University of Würzburg, 97080 Würzburg, Germany.

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For correspondence: sascha.sauer@mdc-berlin.de

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Signals trigger state-specific transcriptional programs to support diversity and homeostasis in immune cells

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