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Research ArticleImmunology
Signals trigger state-specific transcriptional programs to support diversity and homeostasis in immune cells
- View ORCID ProfileCornelius Fischer1,2,3,*,
- View ORCID ProfileMaria Metsger1,2,3,4,*,
- Sophia Bauch1,2,
- Ramon Vidal1,
- Michael Böttcher2,
- View ORCID ProfilePhillip Grote2,5,
- Magdalena Kliem1,2, and
- View ORCID ProfileSascha Sauer1,2,6,†
- 1Laboratory of Functional Genomics, Nutrigenomics and Systems Biology, Scientific Genomics Platforms, Max Delbrück Center for Molecular Medicine (BIMSB/BIH), 13092 Berlin, Germany.
- 2Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.
- 3Department of Biology, Chemistry, and Pharmacy, Free University of Berlin, 14195 Berlin, Germany.
- 4Central European Institute of Technology, Masaryk University, 62500 Brno, Czech Republic.
- 5Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University, 60590 Frankfurt am Main, Germany.
- 6CU Systems Medicine, University of Würzburg, 97080 Würzburg, Germany.
- ↵†Corresponding author. Email: sascha.sauer{at}mdc-berlin.de
↵* These authors contributed equally to this work.
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Science Signaling 14 May 2019:
Vol. 12, Issue 581, eaao5820
DOI: 10.1126/scisignal.aao5820
Vol. 12, Issue 581, eaao5820
DOI: 10.1126/scisignal.aao5820
Cornelius Fischer
1Laboratory of Functional Genomics, Nutrigenomics and Systems Biology, Scientific Genomics Platforms, Max Delbrück Center for Molecular Medicine (BIMSB/BIH), 13092 Berlin, Germany.
2Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.
3Department of Biology, Chemistry, and Pharmacy, Free University of Berlin, 14195 Berlin, Germany.
Maria Metsger
1Laboratory of Functional Genomics, Nutrigenomics and Systems Biology, Scientific Genomics Platforms, Max Delbrück Center for Molecular Medicine (BIMSB/BIH), 13092 Berlin, Germany.
2Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.
3Department of Biology, Chemistry, and Pharmacy, Free University of Berlin, 14195 Berlin, Germany.
4Central European Institute of Technology, Masaryk University, 62500 Brno, Czech Republic.
Sophia Bauch
1Laboratory of Functional Genomics, Nutrigenomics and Systems Biology, Scientific Genomics Platforms, Max Delbrück Center for Molecular Medicine (BIMSB/BIH), 13092 Berlin, Germany.
2Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.
Ramon Vidal
1Laboratory of Functional Genomics, Nutrigenomics and Systems Biology, Scientific Genomics Platforms, Max Delbrück Center for Molecular Medicine (BIMSB/BIH), 13092 Berlin, Germany.
Michael Böttcher
2Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.
Phillip Grote
2Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.
5Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University, 60590 Frankfurt am Main, Germany.
Magdalena Kliem
1Laboratory of Functional Genomics, Nutrigenomics and Systems Biology, Scientific Genomics Platforms, Max Delbrück Center for Molecular Medicine (BIMSB/BIH), 13092 Berlin, Germany.
2Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.
Sascha Sauer
1Laboratory of Functional Genomics, Nutrigenomics and Systems Biology, Scientific Genomics Platforms, Max Delbrück Center for Molecular Medicine (BIMSB/BIH), 13092 Berlin, Germany.
2Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany.
6CU Systems Medicine, University of Würzburg, 97080 Würzburg, Germany.
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