FocusInnate Immunity

The innate immune DNA sensor cGAS: A membrane, cytosolic, or nuclear protein?

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Science Signaling  14 May 2019:
Vol. 12, Issue 581, eaax3521
DOI: 10.1126/scisignal.aax3521

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Abstract

Cyclic cGMP-AMP synthase (cGAS) alerts the innate immune system to the presence of foreign or damaged self-DNA inside the cell and is critical for the outcome of infections, inflammatory diseases, and cancer. Two studies now demonstrate that cGAS activation is regulated by differential subcellular localization through its non-enzymatic, N-terminal domain.

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