Research ArticleFibrosis
mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1–induced collagen biosynthesis
- View ORCID ProfileBrintha Selvarajah1,*,
- View ORCID ProfileIlan Azuelos1,*,
- View ORCID ProfileManuela Platé1,
- Delphine Guillotin1,
- Ellen J. Forty1,
- Greg Contento1,
- View ORCID ProfileHannah V. Woodcock1,
- Matthew Redding1,
- Adam Taylor2,
- Gino Brunori3,
- Pascal F. Durrenberger1,
- View ORCID ProfileRiccardo Ronzoni4,
- View ORCID ProfileAndy D. Blanchard2,
- Paul F. Mercer1,
- View ORCID ProfileDimitrios Anastasiou5, and
- View ORCID ProfileRachel C. Chambers1,†
- 1Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London WC1E 6JF, UK.
- 2Fibrosis Discovery Performance Unit, Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Stevenage SG1 2NY, UK.
- 3GlaxoSmithKline, David Jack Centre for R&D, Park Road, Ware, Hertfordshire, SG12 0DP, UK.
- 4Centre for Respiratory Biology, UCL Respiratory, Rayne Building, University College London, London WC1E 6JF, UK.
- 5Cancer Metabolism Laboratory, Francis Crick Institute, London NW1 1AT, UK.
- ↵†Corresponding author. Email: r.chambers{at}ucl.ac.uk
↵* These authors contributed equally to this work.
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Science Signaling 21 May 2019:
Vol. 12, Issue 582, eaav3048
DOI: 10.1126/scisignal.aav3048
Vol. 12, Issue 582, eaav3048
DOI: 10.1126/scisignal.aav3048
Brintha Selvarajah
1Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London WC1E 6JF, UK.
Ilan Azuelos
1Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London WC1E 6JF, UK.
Manuela Platé
1Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London WC1E 6JF, UK.
Delphine Guillotin
1Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London WC1E 6JF, UK.
Ellen J. Forty
1Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London WC1E 6JF, UK.
Greg Contento
1Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London WC1E 6JF, UK.
Hannah V. Woodcock
1Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London WC1E 6JF, UK.
Matthew Redding
1Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London WC1E 6JF, UK.
Adam Taylor
2Fibrosis Discovery Performance Unit, Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Stevenage SG1 2NY, UK.
Gino Brunori
3GlaxoSmithKline, David Jack Centre for R&D, Park Road, Ware, Hertfordshire, SG12 0DP, UK.
Pascal F. Durrenberger
1Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London WC1E 6JF, UK.
Riccardo Ronzoni
4Centre for Respiratory Biology, UCL Respiratory, Rayne Building, University College London, London WC1E 6JF, UK.
Andy D. Blanchard
2Fibrosis Discovery Performance Unit, Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Stevenage SG1 2NY, UK.
Paul F. Mercer
1Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London WC1E 6JF, UK.
Dimitrios Anastasiou
5Cancer Metabolism Laboratory, Francis Crick Institute, London NW1 1AT, UK.
Rachel C. Chambers
1Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Building, University College London, London WC1E 6JF, UK.
