28 May 2019
Vol 12, Issue 583

About The Cover

Cover image expansion

Online Cover This week features a Research Article that uses functional genomics to identify potential combination therapies with an inhibitor of mutant KRAS, a protein that drives the growth of some cancers and until recently was considered undruggable. The study identifies drugs that either enhance the binding of the inhibitor to its target or block persistent cell survival pathways, with potential to decrease resistance in patients. [Image:]