Contents
28 May 2019
Vol 12, Issue 583
Vol 12, Issue 583
Focus
- Too close not to encyst: Polycystic kidney disease and interorganellar contact sites
Polycystic kidney disease is a disorder of increased mitochondria-ER communication (Kuo et al., in 7 May 2019 issue).
Research Articles
- KRASG12C inhibition produces a driver-limited state revealing collateral dependencies
Functional genomics reveals paths to enhancing combination therapies in KRAS-mutant cancers.
- Flotillin-mediated endocytosis and ALIX–syntenin-1–mediated exocytosis protect the cell membrane from damage caused by necroptosis
Two independent trafficking pathways remove phosphorylated MLKL from the plasma membrane to avert necroptosis.
Editors' Choice
- SOCE, mitochondria, and inflammation
Store-operated calcium entry regulates mitochondrial function to support pathogenic TH17 cells and promote inflammation.
About The Cover
Online Cover This week features a Research Article that uses functional genomics to identify potential combination therapies with an inhibitor of mutant KRAS, a protein that drives the growth of some cancers and until recently was considered undruggable. The study identifies drugs that either enhance the binding of the inhibitor to its target or block persistent cell survival pathways, with potential to decrease resistance in patients. [Image: iStock.com/Phattana]