Flotillin-mediated endocytosis and ALIX–syntenin-1–mediated exocytosis protect the cell membrane from damage caused by necroptosis

Weiliang Fan; Jia Guo; Beichen Gao; Wenbin Zhang; Liucong Ling; Tao Xu; Chenjie Pan; Lin Li; She Chen; Hua Wang; Jing Zhang; Xiaodong Wang

doi:10.1126/scisignal.aaw3423

Research ArticleCell death

Flotillin-mediated endocytosis and ALIX–syntenin-1–mediated exocytosis protect the cell membrane from damage caused by necroptosis

Weiliang Fan¹,²,
Jia Guo¹,²,
Beichen Gao¹,²,
Wenbin Zhang¹,²,
Liucong Ling¹,²,
Tao Xu¹,²,
Chenjie Pan¹,²,
Lin Li¹,²,
She Chen¹,²,
Hua Wang³,⁴,
Jing Zhang³,⁵, and
Xiaodong Wang¹,²,*

¹National Institute of Biological Sciences, Beijing, No. 7 Science Park Road, Zhongguancun Life Science Park, Beijing 102206, China.
²Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 102206, China.
³Department of Pathology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.
⁴Department of Pathology, Peking University Third Hospital, Beijing 100191, China.
⁵Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA.

↵*Corresponding author. Email: wangxiaodong{at}nibs.ac.cn

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Science Signaling 28 May 2019:
Vol. 12, Issue 583, eaaw3423
DOI: 10.1126/scisignal.aaw3423

Weiliang Fan

National Institute of Biological Sciences, Beijing, No. 7 Science Park Road, Zhongguancun Life Science Park, Beijing 102206, China.Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 102206, China.

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Jia Guo

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Beichen Gao

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Wenbin Zhang

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Liucong Ling

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Tao Xu

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Chenjie Pan

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Lin Li

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She Chen

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Hua Wang

Department of Pathology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.Department of Pathology, Peking University Third Hospital, Beijing 100191, China.

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Jing Zhang

Department of Pathology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA.

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Xiaodong Wang

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For correspondence: wangxiaodong@nibs.ac.cn

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Flotillin-mediated endocytosis and ALIX–syntenin-1–mediated exocytosis protect the cell membrane from damage caused by necroptosis

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