FocusINTERORGANELLE SIGNALING

Too close not to encyst: Polycystic kidney disease and interorganellar contact sites

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Science Signaling  28 May 2019:
Vol. 12, Issue 583, eaaw6996
DOI: 10.1126/scisignal.aaw6996

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Abstract

Mitofusin 2 (MFN2) tethers mitochondria to the endoplasmic reticulum (ER). In the 7 May 2019 issue of Science Signaling, Kuo et al. report that polycystin 2 (PC2), encoded by a gene mutated in type 2 autosomal dominant polycystic kidney disease (ADPKD), contributes to cystogenesis by affecting MFN2, thus extending the role of mitochondria-ER contact sites to a common genetic disorder.

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