Contents
04 June 2019
Vol 12, Issue 584
Vol 12, Issue 584
Research Article
- Transcriptional activation of elephant shark mineralocorticoid receptor by corticosteroids, progesterone, and spironolactone
Binding and activity assays suggest a role for progesterone in stimulating the elephant shark mineralocorticoid receptor.
Research Resource
- Design and evaluation of engineered protein biosensors for live-cell imaging of EGFR phosphorylation
Engineered biosensors accurately report the kinetics of EGFR activation.
Editors' Choice
- Cancer and the death domain
Inclusion of a death domain in an alternatively spliced isoform of the kinase IRAK4 increases leukemic burden.
About The Cover
Online Cover This week features a Research Article that examined the binding and activity profiles of a range of corticosteroids and steroid hormones for the mineralocorticoid receptor (MR) of the elephant shark, a cartilaginous fish found in the oldest group of jawed vertebrates. These studies suggest that elephant shark MR is activated by progesterone, implying that the MR may play an unappreciated role in reproductive physiology. The image shows an elephant shark (Callorhinchus milii). [Image: Kelvin Aitken/VWPics/Newscom]