Research ArticleCell Biology

AMPK directly activates mTORC2 to promote cell survival during acute energetic stress

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Science Signaling  11 Jun 2019:
Vol. 12, Issue 585, eaav3249
DOI: 10.1126/scisignal.aav3249

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Surviving energetic stress with mTORC2

The roles and regulation of mTORC2, a multiprotein complex that contains the kinase mTOR in association with rictor, have been enigmatic. Kazyken et al. identified the energy sensor AMPK as a kinase that phosphorylated and activated mTORC2 (see the Focus by Jacinto). Activation of AMPK by energetic stress stimulated mTORC2 and its substrate Akt, thereby promoting cell survival. These results may help to explain why AMPK, which is typically thought of as a tumor suppressor, can act as promoter of tumor growth in some contexts.

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