Research ArticlePain
CDK5 inhibits the clathrin-dependent internalization of TRPV1 by phosphorylating the clathrin adaptor protein AP2μ2
- View ORCID ProfileJiao Liu1,2,*,
- View ORCID ProfileJunxia Du3,*, and
- View ORCID ProfileYun Wang2,4,†
- 1Center of Medical and Health Analysis, Peking University Health Science Center, Beijing 100191, China.
- 2Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, the Key Laboratory for Neuroscience of the Ministry of Education/National Health Commission and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.
- 3College of Biological Science and Engineering, Xingtai University, Xingtai 054001, Hebei Province, China.
- 4PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China.
- ↵†Corresponding author. Email: wangy66{at}bjmu.edu.cn
↵* These authors contributed equally to this work.
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Science Signaling 11 Jun 2019:
Vol. 12, Issue 585, eaaw2040
DOI: 10.1126/scisignal.aaw2040
Vol. 12, Issue 585, eaaw2040
DOI: 10.1126/scisignal.aaw2040
Jiao Liu
1Center of Medical and Health Analysis, Peking University Health Science Center, Beijing 100191, China.
2Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, the Key Laboratory for Neuroscience of the Ministry of Education/National Health Commission and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.
Junxia Du
3College of Biological Science and Engineering, Xingtai University, Xingtai 054001, Hebei Province, China.
Yun Wang
2Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, the Key Laboratory for Neuroscience of the Ministry of Education/National Health Commission and State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.
4PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China.
