FocusCell Biology

Amplifying mTORC2 signals through AMPK during energetic stress

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Science Signaling  11 Jun 2019:
Vol. 12, Issue 585, eaax5855
DOI: 10.1126/scisignal.aax5855

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Abstract

Growth factors activate mTOR complex 2 (mTORC2) through poorly defined mechanisms to modulate cell metabolism. In this issue of Science Signaling, Kazyken et al. now report that AMPK directly activates mTORC2 during energetic stress to enhance cell survival.

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