Research ArticleCardiovascular Biology Depolysulfidation of Drp1 induced by low-dose methylmercury exposure increases cardiac vulnerability to hemodynamic overload View ORCID ProfileAkiyuki Nishimura1,2,3, View ORCID ProfileKakeru Shimoda2,3,4, View ORCID ProfileTomohiro Tanaka2,3,5, View ORCID ProfileTakashi Toyama3,*, Kazuhiro Nishiyama1, Yasuhiro Shinkai6, Takuro Numaga-Tomita2,3,4, Daiju Yamazaki7, Yasunari Kanda7, Takaaki Akaike8, Yoshito Kumagai6, and View ORCID ProfileMotohiro Nishida1,2,3,4,†1Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.2Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences (NINS), Okazaki 444-8787, Japan.3National Institute for Physiological Sciences (NIPS), NINS, Okazaki 444-8787, Japan.4SOKENDAI (School of Life Science, Graduate University for Advanced Studies), Okazaki 444-8787, Japan.5Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.6Center for Novel Science Initiatives (CNSI), NINS, Tokyo 105-0001, Japan.7Division of Pharmacology, National Institute of Health Sciences, Kanagawa, 210-9501, Japan.8Graduate School of Medicine, Tohoku University, Sendai 980-8575, Japan.↵†Corresponding author. Email: nishida{at}nips.ac.jp↵* Present address: Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8575, Japan. See allHide authors and affiliations Science Signaling 25 Jun 2019:Vol. 12, Issue 587, eaaw1920DOI: 10.1126/scisignal.aaw1920 Akiyuki Nishimura 1Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.2Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences (NINS), Okazaki 444-8787, Japan.3National Institute for Physiological Sciences (NIPS), NINS, Okazaki 444-8787, Japan.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Akiyuki Nishimura Kakeru Shimoda 2Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences (NINS), Okazaki 444-8787, Japan.3National Institute for Physiological Sciences (NIPS), NINS, Okazaki 444-8787, Japan.4SOKENDAI (School of Life Science, Graduate University for Advanced Studies), Okazaki 444-8787, Japan.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Kakeru Shimoda Tomohiro Tanaka 2Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences (NINS), Okazaki 444-8787, Japan.3National Institute for Physiological Sciences (NIPS), NINS, Okazaki 444-8787, Japan.5Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Tomohiro Tanaka Takashi Toyama 3National Institute for Physiological Sciences (NIPS), NINS, Okazaki 444-8787, Japan.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Takashi Toyama Kazuhiro Nishiyama 1Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Yasuhiro Shinkai 6Center for Novel Science Initiatives (CNSI), NINS, Tokyo 105-0001, Japan.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Takuro Numaga-Tomita 2Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences (NINS), Okazaki 444-8787, Japan.3National Institute for Physiological Sciences (NIPS), NINS, Okazaki 444-8787, Japan.4SOKENDAI (School of Life Science, Graduate University for Advanced Studies), Okazaki 444-8787, Japan.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Daiju Yamazaki 7Division of Pharmacology, National Institute of Health Sciences, Kanagawa, 210-9501, Japan.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Yasunari Kanda 7Division of Pharmacology, National Institute of Health Sciences, Kanagawa, 210-9501, Japan.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Takaaki Akaike 8Graduate School of Medicine, Tohoku University, Sendai 980-8575, Japan.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Yoshito Kumagai 6Center for Novel Science Initiatives (CNSI), NINS, Tokyo 105-0001, Japan.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Motohiro Nishida 1Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.2Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences (NINS), Okazaki 444-8787, Japan.3National Institute for Physiological Sciences (NIPS), NINS, Okazaki 444-8787, Japan.4SOKENDAI (School of Life Science, Graduate University for Advanced Studies), Okazaki 444-8787, Japan.Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Motohiro Nishida For correspondence: nishida@nips.ac.jp Article Figures & Data Info & Metrics eLetters PDF Article Information vol. 12 no. 587 DOI: https://doi.org/10.1126/scisignal.aaw1920 PubMed: 31239323 Published By: Science Signaling Print ISSN: 1945-0877 Online ISSN: 1937-9145 History: Received November 27, 2018Accepted June 7, 2019 . Copyright & Usage: Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works http://www.sciencemag.org/about/science-licenses-journal-article-reuseThis is an article distributed under the terms of the Science Journals Default License. Author Information Altmetric Article usage Article lifetimeLast 6 monthsThis monthArticle usage: June 2019 to March 2021 AbstractFullPdf Jun 2019294522075 Jul 20198339352 Aug 20191032717 Sep 2019603118 Oct 2019712515 Nov 2019532810 Dec 20191063012 Jan 2020633611 Feb 202054179 Mar 2020683923 Apr 202081248 May 2020952213 Jun 2020484215 Jul 202005928 Aug 202026524 Sep 202046640 Oct 202036527 Nov 202066629 Dec 202068428 Jan 202125828 Feb 202176116 Mar 2021141 View Full Text
Depolysulfidation of Drp1 induced by low-dose methylmercury exposure increases cardiac vulnerability to hemodynamic overload By Akiyuki Nishimura, Kakeru Shimoda, Tomohiro Tanaka, Takashi Toyama, Kazuhiro Nishiyama, Yasuhiro Shinkai, Takuro Numaga-Tomita, Daiju Yamazaki, Yasunari Kanda, Takaaki Akaike, Yoshito Kumagai, Motohiro Nishida Science Signaling25 Jun 2019 Methylmercury precipitates heart failure by increasing Drp1-mediated mitochondrial fission. Supplementary Materials
Depolysulfidation of Drp1 induced by low-dose methylmercury exposure increases cardiac vulnerability to hemodynamic overload By Akiyuki Nishimura, Kakeru Shimoda, Tomohiro Tanaka, Takashi Toyama, Kazuhiro Nishiyama, Yasuhiro Shinkai, Takuro Numaga-Tomita, Daiju Yamazaki, Yasunari Kanda, Takaaki Akaike, Yoshito Kumagai, Motohiro Nishida Science Signaling25 Jun 2019 Methylmercury precipitates heart failure by increasing Drp1-mediated mitochondrial fission. Supplementary Materials