Research ArticleCardiovascular Biology
Depolysulfidation of Drp1 induced by low-dose methylmercury exposure increases cardiac vulnerability to hemodynamic overload
- View ORCID ProfileAkiyuki Nishimura1,2,3,
- View ORCID ProfileKakeru Shimoda2,3,4,
- View ORCID ProfileTomohiro Tanaka2,3,5,
- View ORCID ProfileTakashi Toyama3,*,
- Kazuhiro Nishiyama1,
- Yasuhiro Shinkai6,
- Takuro Numaga-Tomita2,3,4,
- Daiju Yamazaki7,
- Yasunari Kanda7,
- Takaaki Akaike8,
- Yoshito Kumagai6, and
- View ORCID ProfileMotohiro Nishida1,2,3,4,†
- 1Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
- 2Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences (NINS), Okazaki 444-8787, Japan.
- 3National Institute for Physiological Sciences (NIPS), NINS, Okazaki 444-8787, Japan.
- 4SOKENDAI (School of Life Science, Graduate University for Advanced Studies), Okazaki 444-8787, Japan.
- 5Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.
- 6Center for Novel Science Initiatives (CNSI), NINS, Tokyo 105-0001, Japan.
- 7Division of Pharmacology, National Institute of Health Sciences, Kanagawa, 210-9501, Japan.
- 8Graduate School of Medicine, Tohoku University, Sendai 980-8575, Japan.
- ↵†Corresponding author. Email: nishida{at}nips.ac.jp
↵* Present address: Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8575, Japan.
See allHide authors and affiliations
Science Signaling 25 Jun 2019:
Vol. 12, Issue 587, eaaw1920
DOI: 10.1126/scisignal.aaw1920
Vol. 12, Issue 587, eaaw1920
DOI: 10.1126/scisignal.aaw1920
Akiyuki Nishimura
1Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
2Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences (NINS), Okazaki 444-8787, Japan.
3National Institute for Physiological Sciences (NIPS), NINS, Okazaki 444-8787, Japan.
Kakeru Shimoda
2Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences (NINS), Okazaki 444-8787, Japan.
3National Institute for Physiological Sciences (NIPS), NINS, Okazaki 444-8787, Japan.
4SOKENDAI (School of Life Science, Graduate University for Advanced Studies), Okazaki 444-8787, Japan.
Tomohiro Tanaka
2Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences (NINS), Okazaki 444-8787, Japan.
3National Institute for Physiological Sciences (NIPS), NINS, Okazaki 444-8787, Japan.
5Faculty of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.
Takashi Toyama
3National Institute for Physiological Sciences (NIPS), NINS, Okazaki 444-8787, Japan.
Kazuhiro Nishiyama
1Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
Yasuhiro Shinkai
6Center for Novel Science Initiatives (CNSI), NINS, Tokyo 105-0001, Japan.
Takuro Numaga-Tomita
2Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences (NINS), Okazaki 444-8787, Japan.
3National Institute for Physiological Sciences (NIPS), NINS, Okazaki 444-8787, Japan.
4SOKENDAI (School of Life Science, Graduate University for Advanced Studies), Okazaki 444-8787, Japan.
Daiju Yamazaki
7Division of Pharmacology, National Institute of Health Sciences, Kanagawa, 210-9501, Japan.
Yasunari Kanda
7Division of Pharmacology, National Institute of Health Sciences, Kanagawa, 210-9501, Japan.
Takaaki Akaike
8Graduate School of Medicine, Tohoku University, Sendai 980-8575, Japan.
Yoshito Kumagai
6Center for Novel Science Initiatives (CNSI), NINS, Tokyo 105-0001, Japan.
Motohiro Nishida
1Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
2Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences (NINS), Okazaki 444-8787, Japan.
3National Institute for Physiological Sciences (NIPS), NINS, Okazaki 444-8787, Japan.
4SOKENDAI (School of Life Science, Graduate University for Advanced Studies), Okazaki 444-8787, Japan.
