Kynurenine signaling through the aryl hydrocarbon receptor maintains the undifferentiated state of human embryonic stem cells

Takako Yamamoto; Kunitada Hatabayashi; Mao Arita; Nobuyuki Yajima; Chiemi Takenaka; Takashi Suzuki; Masatoshi Takahashi; Yasuhiro Oshima; Keisuke Hara; Kenichi Kagawa; Shin Kawamata

doi:10.1126/scisignal.aaw3306

Research ArticleStem Cells

Kynurenine signaling through the aryl hydrocarbon receptor maintains the undifferentiated state of human embryonic stem cells

Takako Yamamoto¹,
Kunitada Hatabayashi²,
Mao Arita¹,
Nobuyuki Yajima¹,
Chiemi Takenaka¹,
Takashi Suzuki³,
Masatoshi Takahashi³,
Yasuhiro Oshima²,
Keisuke Hara²,
Kenichi Kagawa², and
Shin Kawamata¹,⁴,*

¹Research & Development Center for Cell Therapy, Foundation for Biomedical Research and Innovation, 2-2 Minatojima Minami-machi, Chuo-ku, Kobe 650-0047, Japan.
²Innovative Technology Planning Department, Tokyo Electron Limited, Akasaka Biz Tower, 5-3-1 Akasaka, Minato-Ku, Tokyo 107-6325, Japan.
³Analytical and Measuring Instruments Division, Shimadzu Corporation, 1 Nishinokyo, Kuwahara-cho, Nagagyo-ku, Kyoto 604-8511, Japan.
⁴Riken Center for Developmental Biology, 2-1 Minatojima Minami-machi, Chuo-ku, Kobe 650-0047, Japan.

↵*Corresponding author. Email: kawamata{at}fbri.org

See allHide authors and affiliations

Science Signaling 25 Jun 2019:
Vol. 12, Issue 587, eaaw3306
DOI: 10.1126/scisignal.aaw3306

Takako Yamamoto

Research & Development Center for Cell Therapy, Foundation for Biomedical Research and Innovation, 2-2 Minatojima Minami-machi, Chuo-ku, Kobe 650-0047, Japan.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Takako Yamamoto

Kunitada Hatabayashi

Innovative Technology Planning Department, Tokyo Electron Limited, Akasaka Biz Tower, 5-3-1 Akasaka, Minato-Ku, Tokyo 107-6325, Japan.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Kunitada Hatabayashi

Mao Arita

Research & Development Center for Cell Therapy, Foundation for Biomedical Research and Innovation, 2-2 Minatojima Minami-machi, Chuo-ku, Kobe 650-0047, Japan.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Mao Arita

Nobuyuki Yajima

Research & Development Center for Cell Therapy, Foundation for Biomedical Research and Innovation, 2-2 Minatojima Minami-machi, Chuo-ku, Kobe 650-0047, Japan.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Nobuyuki Yajima

Chiemi Takenaka

Research & Development Center for Cell Therapy, Foundation for Biomedical Research and Innovation, 2-2 Minatojima Minami-machi, Chuo-ku, Kobe 650-0047, Japan.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Chiemi Takenaka

Takashi Suzuki

Analytical and Measuring Instruments Division, Shimadzu Corporation, 1 Nishinokyo, Kuwahara-cho, Nagagyo-ku, Kyoto 604-8511, Japan.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Takashi Suzuki

Masatoshi Takahashi

Analytical and Measuring Instruments Division, Shimadzu Corporation, 1 Nishinokyo, Kuwahara-cho, Nagagyo-ku, Kyoto 604-8511, Japan.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Masatoshi Takahashi

Yasuhiro Oshima

Innovative Technology Planning Department, Tokyo Electron Limited, Akasaka Biz Tower, 5-3-1 Akasaka, Minato-Ku, Tokyo 107-6325, Japan.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Yasuhiro Oshima

Keisuke Hara

Innovative Technology Planning Department, Tokyo Electron Limited, Akasaka Biz Tower, 5-3-1 Akasaka, Minato-Ku, Tokyo 107-6325, Japan.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Keisuke Hara

Kenichi Kagawa

Innovative Technology Planning Department, Tokyo Electron Limited, Akasaka Biz Tower, 5-3-1 Akasaka, Minato-Ku, Tokyo 107-6325, Japan.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Kenichi Kagawa

Shin Kawamata

Research & Development Center for Cell Therapy, Foundation for Biomedical Research and Innovation, 2-2 Minatojima Minami-machi, Chuo-ku, Kobe 650-0047, Japan.Riken Center for Developmental Biology, 2-1 Minatojima Minami-machi, Chuo-ku, Kobe 650-0047, Japan.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Shin Kawamata
For correspondence: kawamata@fbri.org

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Service before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

What code is in the image? Enter the characters shown in the image.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

Kynurenine signaling through the aryl hydrocarbon receptor maintains the undifferentiated state of human embryonic stem cells

Plain text

Vertical Tabs

Science Signaling

Article Tools