Research ArticleNeuroepigenetics

Long noncoding RNA NEAT1 mediates neuronal histone methylation and age-related memory impairment

See allHide authors and affiliations

Science Signaling  02 Jul 2019:
Vol. 12, Issue 588, eaaw9277
DOI: 10.1126/scisignal.aaw9277

On memory and aging

It is an unfortunate aspect of aging that memory tends to decline. Butler et al. identified one way by which that happens. Using mice, mouse hippocampal neurons, and stem cell–derived human neurons, the authors found that the long noncoding RNA NEAT1—which is more commonly associated with cancer—was present in greater amounts in the aged hippocampus and facilitated histone methylation that suppressed the expression of c-FOS, a critical memory-associated gene. Depleting NEAT1 in old mice improved their performance in memory-associated behavior tests, whereas overexpressing NEAT1 in the hippocampus of younger mice impaired performance. These findings reveal a lncRNA-regulated epigenetic mechanism that contributes to age-associated cognitive impairment.

View Full Text

Stay Connected to Science Signaling