Contents
23 July 2019
Vol 12, Issue 591
Vol 12, Issue 591
Research Articles
- Adipocytes sensitize melanoma cells to environmental TGF-β cues by repressing the expression of miR-211
Fat cells secrete cytokines that enhance pro-metastatic TGF-β signaling in melanoma cells.
- Alternative ZAP70-p38 signals prime a classical p38 pathway through LAT and SOS to support regulatory T cell differentiation
“Alternative” ZAP70–dependent activation of the kinase p38 increases activation of the “classical” p38 cascade in T cells.
Editors' Choice
- Bugs in the gut dictate food allergy
Bacteriotherapy that stimulates gut-resident regulatory T cells may suppress food allergies.
About The Cover
Online Cover This week features a Research Article that shows how cytokines secreted by fat cells promote an invasive switch in melanoma cells. The image shows staining of a human melanoma tumor (red) with adjacent fibroblasts (pink) and adipose tissue (green). [Image: Golan et al./Science Signaling]
