Research ArticleCancer
Adipocytes sensitize melanoma cells to environmental TGF-β cues by repressing the expression of miR-211
- View ORCID ProfileTamar Golan1,
- Roma Parikh1,
- Etai Jacob2,3,4,5,
- Hananya Vaknine6,
- View ORCID ProfileValentina Zemser-Werner7,
- View ORCID ProfileDov Hershkovitz7,8,
- Hagar Malcov1,
- Stav Leibou1,
- View ORCID ProfileHadar Reichman1,
- Danna Sheinboim1,
- Ruth Percik8,9,
- View ORCID ProfileSarah Amar6,
- View ORCID ProfileRonen Brenner6,
- View ORCID ProfileShoshana Greenberger10,
- View ORCID ProfileAndrew Kung11,
- View ORCID ProfileMehdi Khaled12, and
- View ORCID ProfileCarmit Levy1,*
- 1Department of Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
- 2The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan 5290002, Israel.
- 3Department of Structural Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.
- 4Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
- 5Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
- 6Institute of Pathology, E. Wolfson Medical Center, Holon 58100, Israel.
- 7Institute of Pathology, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel.
- 8Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
- 9Institute of Endocrinology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
- 10Department of Dermatology, Sheba Medical Center, Tel Hashomer 52621, Israel.
- 11Department of Pediatrics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
- 12INSERM 1186, Gustave Roussy, Université Paris-Saclay, Villejuif 94805, France.
- ↵*Corresponding author. Email: carmitlevy{at}post.tau.ac.il
See allHide authors and affiliations
Science Signaling 23 Jul 2019:
Vol. 12, Issue 591, eaav6847
DOI: 10.1126/scisignal.aav6847
Vol. 12, Issue 591, eaav6847
DOI: 10.1126/scisignal.aav6847
Tamar Golan
1Department of Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
Roma Parikh
1Department of Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
Etai Jacob
2The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan 5290002, Israel.
3Department of Structural Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.
4Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
5Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Hananya Vaknine
6Institute of Pathology, E. Wolfson Medical Center, Holon 58100, Israel.
Valentina Zemser-Werner
7Institute of Pathology, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel.
Dov Hershkovitz
7Institute of Pathology, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel.
8Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
Hagar Malcov
1Department of Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
Stav Leibou
1Department of Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
Hadar Reichman
1Department of Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
Danna Sheinboim
1Department of Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
Ruth Percik
8Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
9Institute of Endocrinology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Sarah Amar
6Institute of Pathology, E. Wolfson Medical Center, Holon 58100, Israel.
Ronen Brenner
6Institute of Pathology, E. Wolfson Medical Center, Holon 58100, Israel.
Shoshana Greenberger
10Department of Dermatology, Sheba Medical Center, Tel Hashomer 52621, Israel.
Andrew Kung
11Department of Pediatrics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Mehdi Khaled
12INSERM 1186, Gustave Roussy, Université Paris-Saclay, Villejuif 94805, France.
Carmit Levy
1Department of Human Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
