Contents
06 August 2019
Vol 12, Issue 593
Vol 12, Issue 593
Research Articles
- IRF6 and TAK1 coordinately promote the activation of HIPK2 to stimulate apoptosis during palate fusion
The kinase HIPK2 promotes cell death that is necessary for proper palate development in mice.
- Disruption of SynGAP–dopamine D1 receptor complexes alters actin and microtubule dynamics and impairs GABAergic interneuron migration
Interaction between a synaptic GTPase and a dopamine receptor facilitates interneuron development.
- The kinase PKD3 provides negative feedback on cholesterol and triglyceride synthesis by suppressing insulin signaling
PKD3 prevents triglyceride and cholesterol accumulation in the liver in response to insulin.
Editors' Choice
- HER2 reduces the STING
The receptor tyrosine kinase HER2 inhibits STING activation and limits the immune response to DNA virus infection and cancer.
About The Cover
Online Cover This week features a Research Article that shows that the kinase HIPK2 is necessary for proper palate development in mice because it stimulates apoptosis of the seam cells located along the boundary where the two palatal shelves meet. The image shows cell nuclei in the embryonic palate after the palatal shelves have fused prior to elimination of the seam cells. [Image: Ke et al./Science Signaling]
