Research ArticleMetabolism
The kinase PKD3 provides negative feedback on cholesterol and triglyceride synthesis by suppressing insulin signaling
- View ORCID ProfileAlexander E. Mayer1,
- View ORCID ProfileMona C. Löffler1,
- View ORCID ProfileAngel E. Loza Valdés1,
- View ORCID ProfileWerner Schmitz2,
- View ORCID ProfileRabih El-Merahbi1,
- View ORCID ProfileJonathan Trujillo Viera1,
- Manuela Erk1,
- Thianzhou Zhang3,*,
- Ursula Braun3,†,
- Mathias Heikenwalder4,
- Michael Leitges3,‡,
- View ORCID ProfileAlmut Schulze2, and
- View ORCID ProfileGrzegorz Sumara1,5,§
- 1Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, 97080 Würzburg, Germany.
- 2Theodor Boveri Institute, Biocenter, University of Würzburg, 97074 Würzburg, Germany.
- 3Biotechnology Centre of Oslo, University of Oslo, 0349 Oslo, Norway.
- 4Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
- 5Nencki Institute of Experimental Biology, PAS, 02-093 Warsaw, Poland.
- ↵§Corresponding author. Email: grzegorz.sumara{at}uni-wuerzburg.de
↵* Present address: Li Ka Shing Knowledge Institute (LKSKI), St. Michael’s Hospital, M5B 1W8 Toronto, Canada.
↵† Present address: National Core Facility for Human Pluripotent Stem Cells, Oslo University Hospital, 0372 Oslo, Norway.
↵‡ Present address: Tier 1 Canada Research Chair in Cell Signalling and Translational Medicine, Memorial University of Newfoundland, A1B 3V6 St. John’s, Canada.
See allHide authors and affiliations
Science Signaling 06 Aug 2019:
Vol. 12, Issue 593, eaav9150
DOI: 10.1126/scisignal.aav9150
Vol. 12, Issue 593, eaav9150
DOI: 10.1126/scisignal.aav9150
Alexander E. Mayer
1Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, 97080 Würzburg, Germany.
Mona C. Löffler
1Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, 97080 Würzburg, Germany.
Angel E. Loza Valdés
1Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, 97080 Würzburg, Germany.
Werner Schmitz
2Theodor Boveri Institute, Biocenter, University of Würzburg, 97074 Würzburg, Germany.
Rabih El-Merahbi
1Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, 97080 Würzburg, Germany.
Jonathan Trujillo Viera
1Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, 97080 Würzburg, Germany.
Manuela Erk
1Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, 97080 Würzburg, Germany.
Thianzhou Zhang
3Biotechnology Centre of Oslo, University of Oslo, 0349 Oslo, Norway.
Ursula Braun
3Biotechnology Centre of Oslo, University of Oslo, 0349 Oslo, Norway.
Mathias Heikenwalder
4Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Michael Leitges
3Biotechnology Centre of Oslo, University of Oslo, 0349 Oslo, Norway.
Almut Schulze
2Theodor Boveri Institute, Biocenter, University of Würzburg, 97074 Würzburg, Germany.
Grzegorz Sumara
1Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, 97080 Würzburg, Germany.
5Nencki Institute of Experimental Biology, PAS, 02-093 Warsaw, Poland.
