Research ArticleMetabolism
The kinase PKD3 provides negative feedback on cholesterol and triglyceride synthesis by suppressing insulin signaling
- Alexander E. Mayer1,
- Mona C. Löffler1,
- Angel E. Loza Valdés1,
- Werner Schmitz2,
- Rabih El-Merahbi1,
- Jonathan Trujillo Viera1,
- Manuela Erk1,
- Thianzhou Zhang3,*,
- Ursula Braun3,†,
- Mathias Heikenwalder4,
- Michael Leitges3,‡,
- Almut Schulze2, and
- Grzegorz Sumara1,5,§
- 1Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, 97080 Würzburg, Germany.
- 2Theodor Boveri Institute, Biocenter, University of Würzburg, 97074 Würzburg, Germany.
- 3Biotechnology Centre of Oslo, University of Oslo, 0349 Oslo, Norway.
- 4Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
- 5Nencki Institute of Experimental Biology, PAS, 02-093 Warsaw, Poland.
- ↵§Corresponding author. Email: grzegorz.sumara{at}uni-wuerzburg.de
↵* Present address: Li Ka Shing Knowledge Institute (LKSKI), St. Michael’s Hospital, M5B 1W8 Toronto, Canada.
↵† Present address: National Core Facility for Human Pluripotent Stem Cells, Oslo University Hospital, 0372 Oslo, Norway.
↵‡ Present address: Tier 1 Canada Research Chair in Cell Signalling and Translational Medicine, Memorial University of Newfoundland, A1B 3V6 St. John’s, Canada.
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Science Signaling 06 Aug 2019:
Vol. 12, Issue 593, eaav9150
DOI: 10.1126/scisignal.aav9150
