Contents
Vol 12, Issue 594
Research Articles
- Muscle-generated BDNF is a sexually dimorphic myokine that controls metabolic flexibility
BDNF produced by skeletal muscle in female mice enables switching of fuel sources during fasting.
- Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression
NEK family kinases target EML4 to ensure faithful chromosome alignment during metaphase.
Review
- Emerging concepts in pseudoenzyme classification, evolution, and signaling
A roadmap for identifying and analyzing pseudoenzymes is proposed for this rapidly expanding field.
Editors' Choice
- Mast cells tune in to quorum sensing
The molecules that bacteria use to coordinate virulence-promoting collective behaviors also activate mast cells.
About The Cover

Online Cover This week features a Review that discusses recent advances in our knowledge of pseudoenzymes and how to accelerate their identification and functional discovery. The image shows an artist's design of a "pseudoenzyme parade." [Image: Jeroen Claus, Phospho Biomedical Animation]