Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression

Rozita Adib; Jessica M. Montgomery; Joseph Atherton; Laura O’Regan; Mark W. Richards; Kees R. Straatman; Daniel Roth; Anne Straube; Richard Bayliss; Carolyn A. Moores; Andrew M. Fry

doi:10.1126/scisignal.aaw2939

Research ArticleMitosis

Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression

View ORCID ProfileRozita Adib ¹,
View ORCID ProfileJessica M. Montgomery¹,
View ORCID ProfileJoseph Atherton²,
Laura O’Regan¹,
View ORCID ProfileMark W. Richards³,
View ORCID ProfileKees R. Straatman⁴,
View ORCID ProfileDaniel Roth⁵,
View ORCID ProfileAnne Straube ⁵,
View ORCID ProfileRichard Bayliss ³,
View ORCID ProfileCarolyn A. Moores ², and
View ORCID ProfileAndrew M. Fry ¹,*

¹Department of Molecular and Cell Biology, University of Leicester, Lancaster Road, Leicester LE1 9HN, UK.
²Institute of Structural and Molecular Biology, Birkbeck College, Malet Street, London WC1E 7HX, UK.
³Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.
⁴Centre for Core Biotechnology Services, University of Leicester, University Road, Leicester LE1 7RH, UK.
⁵Centre for Mechanochemical Cell Biology and Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK.

↵*Corresponding author. Email: amf5{at}le.ac.uk

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Science Signaling 13 Aug 2019:
Vol. 12, Issue 594, eaaw2939
DOI: 10.1126/scisignal.aaw2939

Rozita Adib

1Department of Molecular and Cell Biology, University of Leicester, Lancaster Road, Leicester LE1 9HN, UK.

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Jessica M. Montgomery

1Department of Molecular and Cell Biology, University of Leicester, Lancaster Road, Leicester LE1 9HN, UK.

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Joseph Atherton

2Institute of Structural and Molecular Biology, Birkbeck College, Malet Street, London WC1E 7HX, UK.

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Laura O’Regan

1Department of Molecular and Cell Biology, University of Leicester, Lancaster Road, Leicester LE1 9HN, UK.

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Mark W. Richards

3Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.

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Kees R. Straatman

4Centre for Core Biotechnology Services, University of Leicester, University Road, Leicester LE1 7RH, UK.

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Daniel Roth

5Centre for Mechanochemical Cell Biology and Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK.

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Anne Straube

5Centre for Mechanochemical Cell Biology and Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK.

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Richard Bayliss

3Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.

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Carolyn A. Moores

2Institute of Structural and Molecular Biology, Birkbeck College, Malet Street, London WC1E 7HX, UK.

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Andrew M. Fry

1Department of Molecular and Cell Biology, University of Leicester, Lancaster Road, Leicester LE1 9HN, UK.

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For correspondence: amf5@le.ac.uk

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Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression

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