SMAC mimetics promote NIK-dependent inhibition of CD4+ TH17 cell differentiation

John Rizk; Joseph Kaplinsky; Rasmus Agerholm; Darshana Kadekar; Fredrik Ivars; William W. Agace; W. Wei-Lynn Wong; Matthew J. Szucs; Samuel A. Myers; Steven A. Carr; Ari Waisman; Vasileios Bekiaris

doi:10.1126/scisignal.aaw3469

Research ArticleImmunology

SMAC mimetics promote NIK-dependent inhibition of CD4⁺ T_H17 cell differentiation

John Rizk¹,
Joseph Kaplinsky¹,
Rasmus Agerholm¹,
Darshana Kadekar¹,
Fredrik Ivars²,
William W. Agace¹,²,
W. Wei-Lynn Wong³,
Matthew J. Szucs⁴,
Samuel A. Myers⁴,
Steven A. Carr⁴,
Ari Waisman⁵, and
Vasileios Bekiaris¹,*

¹Department of Health Technology, Technical University of Denmark, Kemitorvet, Building 202, 2800 Kgs Lyngby, Denmark.
²Department of Experimental Medical Science, Lund University, 22184 Lund, Sweden.
³Institute of Experimental Immunology, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland.
⁴Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
⁵Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University of Mainz, Obere Zahlbacher Str. 67, Mainz 55131, Germany.

↵*Corresponding author. Email: vasbek{at}dtu.dk

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Science Signaling 27 Aug 2019:
Vol. 12, Issue 596, eaaw3469
DOI: 10.1126/scisignal.aaw3469

John Rizk

Department of Health Technology, Technical University of Denmark, Kemitorvet, Building 202, 2800 Kgs Lyngby, Denmark.

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Joseph Kaplinsky

Department of Health Technology, Technical University of Denmark, Kemitorvet, Building 202, 2800 Kgs Lyngby, Denmark.

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Rasmus Agerholm

Department of Health Technology, Technical University of Denmark, Kemitorvet, Building 202, 2800 Kgs Lyngby, Denmark.

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Darshana Kadekar

Department of Health Technology, Technical University of Denmark, Kemitorvet, Building 202, 2800 Kgs Lyngby, Denmark.

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Fredrik Ivars

Department of Experimental Medical Science, Lund University, 22184 Lund, Sweden.

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William W. Agace

Department of Health Technology, Technical University of Denmark, Kemitorvet, Building 202, 2800 Kgs Lyngby, Denmark.

Department of Experimental Medical Science, Lund University, 22184 Lund, Sweden.

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W. Wei-Lynn Wong

Institute of Experimental Immunology, University of Zurich, Winterthurerstrasse 190, Zurich, Switzerland.

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Matthew J. Szucs

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

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Samuel A. Myers

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

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Steven A. Carr

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

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Ari Waisman

Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University of Mainz, Obere Zahlbacher Str. 67, Mainz 55131, Germany.

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Vasileios Bekiaris

Department of Health Technology, Technical University of Denmark, Kemitorvet, Building 202, 2800 Kgs Lyngby, Denmark.

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For correspondence: vasbek@dtu.dk

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vol. 12 no. 596

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https://doi.org/10.1126/scisignal.aaw3469

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Received December 11, 2018
Accepted August 7, 2019
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Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works http://www.sciencemag.org/about/science-licenses-journal-article-reuseThis is an article distributed under the terms of the Science Journals Default License.

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SMAC mimetics promote NIK-dependent inhibition of CD4⁺ T_H17 cell differentiation

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