SMAC mimetics throw a molecular switch to control TH17 responses

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Science Signaling  27 Aug 2019:
Vol. 12, Issue 596, eaay3986
DOI: 10.1126/scisignal.aay3986

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IL-17 produced by TH17 cells plays a central role in numerous protective and pathologic immune responses. In this issue of Science Signaling, Rizk et al. define a molecular switch controlled by the cellular inhibitor of apoptosis proteins that regulates TH17 immunity.

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