Contents
03 September 2019
Vol 12, Issue 597
Vol 12, Issue 597
Research Articles
- The induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2-deoxyglucose
An evolutionarily conserved family of phosphatases enables cells to resist the toxic metabolic effects of 2-deoxyglucose.
- Structure-function guided modeling of chemokine-GPCR specificity for the chemokine XCL1 and its receptor XCR1
Key amino acids in the chemokine XCL1 mediate its specificity for and activation of its receptor XCR1.
- Diacylglycerol kinase ζ promotes allergic airway inflammation and airway hyperresponsiveness through distinct mechanisms
Allergic inflammation and airway hyperresponsiveness in asthma are independently exacerbated by DGK activity.
Editors' Choice
- Visualizing G protein activation
Structures provide insights into the mechanism by which the GPCR rhodopsin activates the G protein transducin.
About The Cover
Online Cover This week features a Research Article that shows that an evolutionarily conserved family of phosphatases enables cells to resist the toxic metabolic effects of 2-deoxyglucose (2-DG). The image shows the footprint left after washing by a colony of yeast with a mutation in cyc8, a transcriptional co-repressor that suppresses the expression of genes encoding 2-DG–detoxifying phosphatases. [Image: Sébastien Léon/Institute Jacques Monod, CNRS, France]
