Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C

Laura F. Bennett; Chang Liao; Michael D. Quickel; Beng San Yeoh; Matam Vijay-Kumar; Pamela Hankey-Giblin; K. Sandeep Prabhu; Robert F. Paulson

doi:10.1126/scisignal.aap7336

Research ArticleInflammation

Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C

Laura F. Bennett ¹,²,
Chang Liao²,³,⁴,*,
Michael D. Quickel ²,³,⁵,
Beng San Yeoh⁶,†,
Matam Vijay-Kumar ⁴,⁶,⁷,†,
Pamela Hankey-Giblin¹,²,³,⁴,
K. Sandeep Prabhu²,³,⁴,⁶, and
Robert F. Paulson ¹,²,⁴,⁶,‡

¹Intercollege Graduate Program in Genetics, Penn State University, University Park, PA 16802, USA.
²Department of Veterinary and Biomedical Sciences, Penn State University, University Park, PA 16802, USA.
³Graduate Program in Pathobiology, Penn State University, University Park, PA 16802, USA.
⁴Center for Molecular Immunology and Infectious Disease, Penn State University, University Park, PA 16802, USA.
⁵Clinical and Translational Science Institute, Penn State College of Medicine, Hershey, PA 17033, USA.
⁶Graduate Program in Molecular, Cellular and Integrative Biosciences, Penn State University, University Park, PA 16802, USA.
⁷Department of Nutritional Sciences, Penn State University, University Park, PA 16802, USA.

↵‡Corresponding author. Email: rfp5{at}psu.edu

↵* Present address: Department of Medicine, University California, San Francisco, San Francisco, CA 94143, USA.
↵† Present address: Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.

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Science Signaling 10 Sep 2019:
Vol. 12, Issue 598, eaap7336
DOI: 10.1126/scisignal.aap7336

Laura F. Bennett

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Chang Liao

Department of Veterinary and Biomedical Sciences, Penn State University, University Park, PA 16802, USA.Graduate Program in Pathobiology, Penn State University, University Park, PA 16802, USA.Center for Molecular Immunology and Infectious Disease, Penn State University, University Park, PA 16802, USA.

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Michael D. Quickel

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Beng San Yeoh

Graduate Program in Molecular, Cellular and Integrative Biosciences, Penn State University, University Park, PA 16802, USA.

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Matam Vijay-Kumar

Center for Molecular Immunology and Infectious Disease, Penn State University, University Park, PA 16802, USA.Graduate Program in Molecular, Cellular and Integrative Biosciences, Penn State University, University Park, PA 16802, USA.Department of Nutritional Sciences, Penn State University, University Park, PA 16802, USA.

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Pamela Hankey-Giblin

Intercollege Graduate Program in Genetics, Penn State University, University Park, PA 16802, USA.Department of Veterinary and Biomedical Sciences, Penn State University, University Park, PA 16802, USA.Graduate Program in Pathobiology, Penn State University, University Park, PA 16802, USA.Center for Molecular Immunology and Infectious Disease, Penn State University, University Park, PA 16802, USA.

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K. Sandeep Prabhu

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Robert F. Paulson

Intercollege Graduate Program in Genetics, Penn State University, University Park, PA 16802, USA.Department of Veterinary and Biomedical Sciences, Penn State University, University Park, PA 16802, USA.Center for Molecular Immunology and Infectious Disease, Penn State University, University Park, PA 16802, USA.Graduate Program in Molecular, Cellular and Integrative Biosciences, Penn State University, University Park, PA 16802, USA.

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For correspondence: rfp5@psu.edu

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