Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C

Laura F. Bennett; Chang Liao; Michael D. Quickel; Beng San Yeoh; Matam Vijay-Kumar; Pamela Hankey-Giblin; K. Sandeep Prabhu; Robert F. Paulson

doi:10.1126/scisignal.aap7336

Research ArticleInflammation

Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C

View ORCID ProfileLaura F. Bennett ¹,²,
View ORCID ProfileChang Liao²,³,⁴,*,
Michael D. Quickel ²,³,⁵,
View ORCID ProfileBeng San Yeoh⁶,†,
Matam Vijay-Kumar ⁴,⁶,⁷,†,
View ORCID ProfilePamela Hankey-Giblin¹,²,³,⁴,
K. Sandeep Prabhu²,³,⁴,⁶, and
View ORCID ProfileRobert F. Paulson ¹,²,⁴,⁶,‡

¹Intercollege Graduate Program in Genetics, Penn State University, University Park, PA 16802, USA.
²Department of Veterinary and Biomedical Sciences, Penn State University, University Park, PA 16802, USA.
³Graduate Program in Pathobiology, Penn State University, University Park, PA 16802, USA.
⁴Center for Molecular Immunology and Infectious Disease, Penn State University, University Park, PA 16802, USA.
⁵Clinical and Translational Science Institute, Penn State College of Medicine, Hershey, PA 17033, USA.
⁶Graduate Program in Molecular, Cellular and Integrative Biosciences, Penn State University, University Park, PA 16802, USA.
⁷Department of Nutritional Sciences, Penn State University, University Park, PA 16802, USA.

↵‡Corresponding author. Email: rfp5{at}psu.edu

↵* Present address: Department of Medicine, University California, San Francisco, San Francisco, CA 94143, USA.
↵† Present address: Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.

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Science Signaling 10 Sep 2019:
Vol. 12, Issue 598, eaap7336
DOI: 10.1126/scisignal.aap7336

Laura F. Bennett

1Intercollege Graduate Program in Genetics, Penn State University, University Park, PA 16802, USA.

2Department of Veterinary and Biomedical Sciences, Penn State University, University Park, PA 16802, USA.

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ORCID record for Laura F. Bennett

Chang Liao

2Department of Veterinary and Biomedical Sciences, Penn State University, University Park, PA 16802, USA.

3Graduate Program in Pathobiology, Penn State University, University Park, PA 16802, USA.

4Center for Molecular Immunology and Infectious Disease, Penn State University, University Park, PA 16802, USA.

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ORCID record for Chang Liao

Michael D. Quickel

2Department of Veterinary and Biomedical Sciences, Penn State University, University Park, PA 16802, USA.

3Graduate Program in Pathobiology, Penn State University, University Park, PA 16802, USA.

5Clinical and Translational Science Institute, Penn State College of Medicine, Hershey, PA 17033, USA.

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Beng San Yeoh

6Graduate Program in Molecular, Cellular and Integrative Biosciences, Penn State University, University Park, PA 16802, USA.

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ORCID record for Beng San Yeoh

Matam Vijay-Kumar

4Center for Molecular Immunology and Infectious Disease, Penn State University, University Park, PA 16802, USA.

6Graduate Program in Molecular, Cellular and Integrative Biosciences, Penn State University, University Park, PA 16802, USA.

7Department of Nutritional Sciences, Penn State University, University Park, PA 16802, USA.

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Pamela Hankey-Giblin

1Intercollege Graduate Program in Genetics, Penn State University, University Park, PA 16802, USA.

2Department of Veterinary and Biomedical Sciences, Penn State University, University Park, PA 16802, USA.

3Graduate Program in Pathobiology, Penn State University, University Park, PA 16802, USA.

4Center for Molecular Immunology and Infectious Disease, Penn State University, University Park, PA 16802, USA.

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K. Sandeep Prabhu

2Department of Veterinary and Biomedical Sciences, Penn State University, University Park, PA 16802, USA.

3Graduate Program in Pathobiology, Penn State University, University Park, PA 16802, USA.

4Center for Molecular Immunology and Infectious Disease, Penn State University, University Park, PA 16802, USA.

6Graduate Program in Molecular, Cellular and Integrative Biosciences, Penn State University, University Park, PA 16802, USA.

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Robert F. Paulson

1Intercollege Graduate Program in Genetics, Penn State University, University Park, PA 16802, USA.

2Department of Veterinary and Biomedical Sciences, Penn State University, University Park, PA 16802, USA.

4Center for Molecular Immunology and Infectious Disease, Penn State University, University Park, PA 16802, USA.

6Graduate Program in Molecular, Cellular and Integrative Biosciences, Penn State University, University Park, PA 16802, USA.

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ORCID record for Robert F. Paulson
For correspondence: rfp5@psu.edu

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