Contents
17 September 2019
Vol 12, Issue 599
Vol 12, Issue 599
Focus
- Full focus on calcium
A conference was held on the complex mechanisms underlying intracellular Ca2+ signaling.
Research Article
- Tumor-derived TGF-β inhibits mitochondrial respiration to suppress IFN-γ production by human CD4+ T cells
The mitochondrial activity and antitumor function of human helper T cells are suppressed by a tumor-derived cytokine.
Review
- Targeting of host cell receptor tyrosine kinases by intracellular pathogens
Intracellular pathogens target host receptor tyrosine kinases to enter host cells and suppress innate immunity.
Editors' Choice
- Coming out of the cold
A glutamate receptor acts as a cold sensor through a channel-independent, G protein–dependent mechanism.
About The Cover
Online Cover This week features a Research Article that shows that the tumor-derived cytokine TGF-β inhibits mitochondrial respiration in CD4+ T lymphocytes, leading to reduced IFN-γ production and suppressed antitumor immunity. The image is a transmission electron micrograph of a lymphocyte with the mitochondria stained purple. [Image: Don W. Fawcett/Science Source]
