Contents
24 September 2019
Vol 12, Issue 600
Vol 12, Issue 600
Research Articles
- A systems mechanism for KRAS mutant allele–specific responses to targeted therapy
A weak KRASG13D-NF1 interaction explains why EGFR inhibitors show efficacy in certain CRC patients.
- Brain-derived neurotrophic factor stimulation of T-type Ca2+ channels in sensory neurons contributes to increased peripheral pain sensitivity
A cross-pathway kinase cascade involving T-type Ca2+ channels may underlie some forms of neuralgia.
Editors' Choice
- Organelle contacts for lipid mobilization
Interorganellar cross-talk controls the storage and mobilization of lipids in fruitflies.
About The Cover
Online Cover This week features a Research Article that reveals that the weak interaction of KRASG13D with the tumor suppressor NF1 underlies the efficacy of EGFR inhibitors in colorectal cancer patients with this mutation. The image shows a cross section of a colorectal polyp, a growth that may develop into colorectal cancer. [Image: Steve Gschmeissner/Science Source]
