Contents
01 October 2019
Vol 12, Issue 601
Vol 12, Issue 601
Research Articles
- HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species
Blocking the kinases CDK4 and CDK6 may be a more broadly applicable therapy for patients with ccRCC.
- LGP2 binds to PACT to regulate RIG-I– and MDA5-mediated antiviral responses
The interaction between LGP2 and a component of the RNA-silencing machinery enables coordination of innate immune responses.
Editors' Choice
- Stress, age, and cancer
Stress and advanced age suppress interferon-mediated antitumor immune surveillance and therapy.
About The Cover
Online Cover This week features a Research Article that suggests a potential therapy for patients with clear cell renal cell carcinoma (ccRCC). Experiments with human ccRCC cells and patient-derived xenografts in mice showed that combined inhibition of the enzymes CDK4 and CDK6 impaired tumor cell growth. The image shows renal cell carcinoma. [Image: vetpathologist/shutterstock.com]
