LGP2 binds to PACT to regulate RIG-I– and MDA5-mediated antiviral responses

Raul Y. Sanchez David; Chantal Combredet; Valérie Najburg; Gael A. Millot; Guillaume Beauclair; Benno Schwikowski; Thibaut Léger; Jean-Michel Camadro; Yves Jacob; Jacques Bellalou; Nolwenn Jouvenet; Frédéric Tangy; Anastassia V. Komarova

doi:10.1126/scisignal.aar3993

Research ArticleImmunology

LGP2 binds to PACT to regulate RIG-I– and MDA5-mediated antiviral responses

View ORCID ProfileRaul Y. Sanchez David ¹,²,*,†,
View ORCID ProfileChantal Combredet¹,*,
Valérie Najburg¹,
View ORCID ProfileGael A. Millot³,
View ORCID ProfileGuillaume Beauclair¹,
View ORCID ProfileBenno Schwikowski⁴,
View ORCID ProfileThibaut Léger⁵,
View ORCID ProfileJean-Michel Camadro⁵,⁶,
View ORCID ProfileYves Jacob⁷,
View ORCID ProfileJacques Bellalou⁸,
View ORCID ProfileNolwenn Jouvenet¹,
View ORCID ProfileFrédéric Tangy¹,‡, and
View ORCID ProfileAnastassia V. Komarova¹,‡

¹Unité de Génomique Virale et Vaccination, Institut Pasteur, CNRS UMR-3569, Paris, France.
²Ecole doctorale B3MI/Paris7, Paris, France.
³Hub de Bioinformatique et Biostatistique–C3BI, Institut Pasteur, USR 3756 CNRS, Paris, France.
⁴Systems Biology Laboratory and USR 3756, Institut Pasteur and CNRS, Paris, France.
⁵Mass Spectrometry Laboratory, Institut Jacques Monod, UMR 7592, Univ Paris Diderot, CNRS, Sorbonne Paris Cité, F-75205 Paris, France.
⁶Mitochondria, Metals, and Oxidative Stress Group, Institut Jacques Monod, UMR 7592, Université Paris Diderot, CNRS, Sorbonne Paris Cité, F-75205 Paris, France.
⁷Unité de Génétique Moléculaire des Virus à ARN, Institut Pasteur, Paris, France.
⁸Platform of Recombinant Proteins in Prokaryotic Cells, Institut Pasteur, 75015, CNRS UMR 3528, Paris, France.

↵‡Corresponding author. Email: frederic.tangy{at}pasteur.fr (F.T.); stasy{at}pasteur.fr (A.V.K.)

↵* These authors contributed equally to this work.
↵† Present address: Section of Virology, Department of Medicine, Imperial College London, London, UK.

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Science Signaling 01 Oct 2019:
Vol. 12, Issue 601, eaar3993
DOI: 10.1126/scisignal.aar3993

Raul Y. Sanchez David

1Unité de Génomique Virale et Vaccination, Institut Pasteur, CNRS UMR-3569, Paris, France.

2Ecole doctorale B3MI/Paris7, Paris, France.

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Chantal Combredet

1Unité de Génomique Virale et Vaccination, Institut Pasteur, CNRS UMR-3569, Paris, France.

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ORCID record for Chantal Combredet

Valérie Najburg

1Unité de Génomique Virale et Vaccination, Institut Pasteur, CNRS UMR-3569, Paris, France.

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Gael A. Millot

3Hub de Bioinformatique et Biostatistique–C3BI, Institut Pasteur, USR 3756 CNRS, Paris, France.

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Guillaume Beauclair

1Unité de Génomique Virale et Vaccination, Institut Pasteur, CNRS UMR-3569, Paris, France.

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Benno Schwikowski

4Systems Biology Laboratory and USR 3756, Institut Pasteur and CNRS, Paris, France.

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Thibaut Léger

5Mass Spectrometry Laboratory, Institut Jacques Monod, UMR 7592, Univ Paris Diderot, CNRS, Sorbonne Paris Cité, F-75205 Paris, France.

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Jean-Michel Camadro

5Mass Spectrometry Laboratory, Institut Jacques Monod, UMR 7592, Univ Paris Diderot, CNRS, Sorbonne Paris Cité, F-75205 Paris, France.

6Mitochondria, Metals, and Oxidative Stress Group, Institut Jacques Monod, UMR 7592, Université Paris Diderot, CNRS, Sorbonne Paris Cité, F-75205 Paris, France.

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Yves Jacob

7Unité de Génétique Moléculaire des Virus à ARN, Institut Pasteur, Paris, France.

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Jacques Bellalou

8Platform of Recombinant Proteins in Prokaryotic Cells, Institut Pasteur, 75015, CNRS UMR 3528, Paris, France.

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Nolwenn Jouvenet

1Unité de Génomique Virale et Vaccination, Institut Pasteur, CNRS UMR-3569, Paris, France.

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Frédéric Tangy

1Unité de Génomique Virale et Vaccination, Institut Pasteur, CNRS UMR-3569, Paris, France.

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For correspondence: frederic.tangy@pasteur.fr stasy@pasteur.fr

Anastassia V. Komarova

1Unité de Génomique Virale et Vaccination, Institut Pasteur, CNRS UMR-3569, Paris, France.

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ORCID record for Anastassia V. Komarova
For correspondence: frederic.tangy@pasteur.fr stasy@pasteur.fr

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LGP2 binds to PACT to regulate RIG-I– and MDA5-mediated antiviral responses

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