Research ArticleCancer therapy

HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species

See allHide authors and affiliations

Science Signaling  01 Oct 2019:
Vol. 12, Issue 601, eaay0482
DOI: 10.1126/scisignal.aay0482

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

New treatment for kidney cancer

People with von Hippel-Lindau syndrome, caused by loss of the namesake gene VHL, commonly develop cysts in the kidneys and are at an increased risk of developing a type of kidney cancer called clear cell renal cell carcinoma (ccRCC). Currently, drugs that inhibit the hypoxia-inducible transcription factor HIF-2α show some efficacy but only in some patients. Nicholson et al. performed a screen to identify targets that selectively limited the growth of VHL−/− fly cells. Confirmed in human ccRCC cells and patient-derived xenografts in mice, they found that inhibiting the cyclin-dependent kinases CDK4 and CDK6 together impaired tumor growth in VHL−/− ccRCC regardless of HIF-2α dependency. These findings suggest a potential and more broadly applicable therapy for ccRCC patients.

View Full Text

Stay Connected to Science Signaling


Editor's Blog