Contents
08 October 2019
Vol 12, Issue 602
Vol 12, Issue 602
Research Articles
- T cell–derived soluble glycoprotein GPIbα mediates PGE2 production in human monocytes activated with the vaccine adjuvant MDP
A T cell–derived glycoprotein induces a monocytic inflammatory response to a vaccine adjuvant.
- CARD9 mediates dendritic cell–induced development of Lyn deficiency–associated autoimmune and inflammatory diseases
Without the kinase Lyn, the adaptor protein CARD9 amplifies cytokine production in autoimmune disease.
- The Ca2+ export pump PMCA clears near-membrane Ca2+ to facilitate store-operated Ca2+ entry and NFAT activation
The Ca2+ export pump PMCA4 unexpectedly facilitates Ca2+ entry and NFAT activation in T cells.
Editors' Choice
- PAF and the inflammasome
The phospholipid PAF stimulates NLRP3 inflammasome activation and inflammatory cytokine production independently of its GPCR.
About The Cover
Online Cover This week features a Research Article that shows that a T cell–derived glycoprotein induces a monocytic inflammatory response to a vaccine adjuvant, which may underlie adverse vaccine reactions in humans. The image shows a child receiving a vaccine. [Image: iStock.com/Mike_Kiev]
