Research ArticleImmunology

CARD9 mediates dendritic cell–induced development of Lyn deficiency–associated autoimmune and inflammatory diseases

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Science Signaling  08 Oct 2019:
Vol. 12, Issue 602, eaao3829
DOI: 10.1126/scisignal.aao3829

Lyn-deficient autoimmunity shows its CARDs

Both the adaptor protein CARD9 and loss of the kinase Lyn are associated with autoimmune disease, notably inflammatory bowel disease. Ma et al. explored this connection in mice and found that CARD9 amplified Toll-like receptor signaling and subsequent cytokine production in Lyn-deficient bone marrow–derived dendritic cells, but not in macrophages. Deleting Card9 or genes encoding Src family kinases in dendritic cells prevented the development of Lyn deficiency–associated colitis in mice. These findings suggest that targeting CARD9 or its associated kinases may therapeutically relieve inflammation in patients with autoimmune disease and that exploring the biological consequences of CARD9 polymorphisms is warranted.

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