Research ArticleImmunology

T cell–derived soluble glycoprotein GPIbα mediates PGE2 production in human monocytes activated with the vaccine adjuvant MDP

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Science Signaling  08 Oct 2019:
Vol. 12, Issue 602, eaat6023
DOI: 10.1126/scisignal.aat6023

Vaccine reactions are a multicellular affair

Vaccine adjuvants can cause adverse, sometimes life-threatening, immune reactions in patients. The adjuvant MDP activates monocytes to release an inflammatory prostaglandin and cytokines. However, Liu et al. found that MDP administration to human monocytes alone was insufficient to produce the prostaglandin response that they saw when it was administered to rabbits. Instead, the authors found that MDP induced T cells to release the glycoprotein GPIbα (better known in platelets), which stimulated Ca2+ signaling by a receptor on the monocytes, resulting in prostaglandin production. Knocking out the GPIbα receptor prevented the inflammatory response to MDP in mice. This multicellular mechanism may underlie adverse vaccine reactions in humans.

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