Contents
15 October 2019
Vol 12, Issue 603
Vol 12, Issue 603
Focus
- Tuning the regulator: Phosphorylation of KCC2 at two specific sites is critical for neurodevelopment
Phosphorylation of the K+/Cl− cotransporter KCC2 underlies neurodevelopmental pathologies (Watanabe et al. and Pisella et al., in 15 October 2019 issue).
Research Articles
- Developmentally regulated KCC2 phosphorylation is essential for dynamic GABA-mediated inhibition and survival
Homozygous knockin mice reveal critical regulation of the neuronal channel KCC2 in synaptic development.
- Impaired regulation of KCC2 phosphorylation leads to neuronal network dysfunction and neurodevelopmental pathology
Heterozygous knockin mice reveal role of the neuronal channel KCC2 in social and cognitive development.
Editors' Choice
- The new cartography
Quantitative proteomics maps previously unappreciated interactions stimulated by T cell activation.
About The Cover
Online Cover This week features two Research Articles by Watanabe et al. and Pisella et al. that show that the dephosphorylation of two critical regulatory sites in the K+/Cl–cotransporter KCC2 during CNS development in mice is important for the maturation of the neurocircuitry required for cognition, respiration, and other aspects of neurological physiology (see also the associated Focus by Zamponi). The image shows H&E-stained sections of mice. [Image: Watanabe et al./Science Signaling]
