Research ArticleNEURODEVELOPMENT
Developmentally regulated KCC2 phosphorylation is essential for dynamic GABA-mediated inhibition and survival
- View ORCID ProfileMiho Watanabe1,*,
- View ORCID ProfileJinwei Zhang2,*,
- View ORCID ProfileM. Shahid Mansuri3,*,
- View ORCID ProfileJingjing Duan4,
- Jason K. Karimy3,
- View ORCID ProfileEric Delpire5,
- View ORCID ProfileSeth L. Alper6,7,
- Richard P. Lifton8,9,
- View ORCID ProfileAtsuo Fukuda1,10,†, and
- View ORCID ProfileKristopher T. Kahle11,†
- 1Department of Neurophysiology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan.
- 2Institute of Biomedical and Clinical Sciences, Medical School, College of Medicine and Health, University of Exeter, Hatherly Laboratories, Exeter EX4 4PS, UK.
- 3Department of Neurosurgery, Yale School of Medicine, New Haven, CT 06510, USA.
- 4Human Aging Research Institute, School of Life Sciences, Nanchang University, Nanchang, Jiangxi 330031, China.
- 5Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
- 6Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
- 7The Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- 8Laboratory of Human Genetics and Genomics, The Rockefeller University, New York, NY, USA.
- 9Department of Genetics, Yale University School of Medicine, New Haven, CT 06511, USA.
- 10Advanced Research Facilities and Services, Preeminent Medical Photonics Education and Research Center, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan.
- 11Departments of Neurosurgery, Pediatrics, and Cellular and Molecular Physiology, Centers for Mendelian Genomics, Yale School of Medicine, New Haven, CT 06510, USA.
- ↵†Corresponding author. Email: kristopher.kahle{at}yale.edu (K.T.K.); axfukuda{at}hama-med.ac.jp (A.F.)
↵* These authors contributed equally to this work.
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Science Signaling 15 Oct 2019:
Vol. 12, Issue 603, eaaw9315
DOI: 10.1126/scisignal.aaw9315
Vol. 12, Issue 603, eaaw9315
DOI: 10.1126/scisignal.aaw9315
Miho Watanabe
1Department of Neurophysiology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan.
Jinwei Zhang
2Institute of Biomedical and Clinical Sciences, Medical School, College of Medicine and Health, University of Exeter, Hatherly Laboratories, Exeter EX4 4PS, UK.
M. Shahid Mansuri
3Department of Neurosurgery, Yale School of Medicine, New Haven, CT 06510, USA.
Jingjing Duan
4Human Aging Research Institute, School of Life Sciences, Nanchang University, Nanchang, Jiangxi 330031, China.
Jason K. Karimy
3Department of Neurosurgery, Yale School of Medicine, New Haven, CT 06510, USA.
Eric Delpire
5Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Seth L. Alper
6Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
7The Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Richard P. Lifton
8Laboratory of Human Genetics and Genomics, The Rockefeller University, New York, NY, USA.
9Department of Genetics, Yale University School of Medicine, New Haven, CT 06511, USA.
Atsuo Fukuda
1Department of Neurophysiology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan.
10Advanced Research Facilities and Services, Preeminent Medical Photonics Education and Research Center, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan.
Kristopher T. Kahle
11Departments of Neurosurgery, Pediatrics, and Cellular and Molecular Physiology, Centers for Mendelian Genomics, Yale School of Medicine, New Haven, CT 06510, USA.