Tuning the regulator: Phosphorylation of KCC2 at two specific sites is critical for neurodevelopment

Gerald W. Zamponi

doi:10.1126/scisignal.aay8960

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Abstract

The K⁺/Cl⁻ cotransporter KCC2 is a molecular switch between excitatory and inhibitory effects of GABAergic inputs into neurons. In a pair of exciting studies, Watanabe et al. and Pisella et al. elucidate the role of KCC2 dephosphorylation in this process and reveal its consequences for neurodevelopment and nervous system pathology.

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Phosphorylation of the K⁺/Cl⁻ cotransporter KCC2 underlies neurodevelopmental pathologies (Watanabe et al. and Pisella et al., in 15 October 2019 issue).

Tuning the regulator: Phosphorylation of KCC2 at two specific sites is critical for neurodevelopment

Abstract

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