Research ArticleImmunometabolism

Induction of metabolic quiescence defines the transitional to follicular B cell switch

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Science Signaling  22 Oct 2019:
Vol. 12, Issue 604, eaaw5573
DOI: 10.1126/scisignal.aaw5573

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AMPing up B cell maturation

Glycolysis provides an important energy source during B cell activation. In contrast, Farmer et al. found that metabolic quiescence was important for the development of human follicular B cells from transitional B cell precursors. In comparison to transitional B cells, mouse and human follicular B cells had reduced expression of genes involved in aerobic respiration, increased AMPK activation, and greater amounts of the cell surface ectoenzymes CD39 and CD73, which generate extracellular adenosine. Transitional human B cells that expressed CD73 or were treated with an AMPK agonist preferentially acquired a follicular B cell phenotype. These data identify a previously uncharacterized metabolic checkpoint in B cell development.

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