Contents
Vol 12, Issue 605
Focus
- iRhom2 and TNF: Partners or enemies?
iRhom2 inhibits proinflammatory signaling that stimulates liver fibrosis (Sundaram et al., in 29 October 2019 issue).
Research Articles
- iRhom2 inhibits bile duct obstruction–induced liver fibrosis
iRhom2 reduces hepatic stellate cell activation and liver fibrosis after bile duct ligation.
- TLR7 and TLR8 activate distinct pathways in monocytes during RNA virus infection
Differences in TLR7 and TLR8 signaling program virus-specific responses of human monocytes to infection.
Editors' Choice
- Inflammation induces stem cell quiescence
Chronic inflammation causes olfactory stem cells to become quiescent and secrete immunomodulatory cytokines.
About The Cover

Online Cover This week features a Research Article that describes how distinct pathways stimulated by the related intracellular RNA receptors TLR7 and TLR8 promote virus-specific responses of human monocytes to RNA virus infection. The image shows a colored scanning electron micrograph of monocytes. [Image: David McCarthy/Science Source]