FocusFibrosis

iRhom2 and TNF: Partners or enemies?

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Science Signaling  29 Oct 2019:
Vol. 12, Issue 605, eaaz0444
DOI: 10.1126/scisignal.aaz0444

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Abstract

iRhom2 is an essential cofactor for ADAM17, the metalloprotease that sheds both the proinflammatory cytokine tumor necrosis factor–α (TNF-α) and TNF receptors (TNFRs) from the cell surface. In this issue of Science Signaling, Sundaram et al. demonstrate a protective role for iRhom2 in promoting ADAM17-mediated shedding of TNFRs in hepatic stellate cells, which reduces TNFR signaling and liver fibrosis in response to injury.

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