12 November 2019
Vol 12, Issue 607

About The Cover

Cover image expansion

Online Cover This week features a Research Article that reports that TGF-β–dependent, profibrotic signaling by the mechanosensitive ion channel TRPV4 requires TRPV4-PI3Kγ complexes at the plasma membrane. The image shows F-actin (red) and the myofibroblast marker α-SMA (green) in mouse lung fibroblasts stimulated with TGF-β. [Image: Grove et al./Science Signaling]