19 November 2019
Vol 12, Issue 608

About The Cover

Cover image expansion

Online Cover This week features a Research Article that reveals how disease-associated mutations in the endoplasmic reticulum–localized Ca2+ sensor STIM1 alter its conformation and disrupt Ca2+ ion binding. The image is a snapshot from molecular dynamics simulations showing the Ca2+ ions around the canonical EF hand (red ribbons), noncanonical EF hand (violet ribbons), and SAM domain (orange ribbons) of STIM1. The Ca2+ ions surrounding the canonical EF hand, noncanonical EF hand, and SAM domain are represented by red, green, and white circles, respectively. [Image: Schober et al./Science Signaling]