Research ArticleCalcium signaling
Sequential activation of STIM1 links Ca2+ with luminal domain unfolding
- Romana Schober1,*,
- Daniel Bonhenry2,*,
- Victoria Lunz1,
- Jinhui Zhu3,4,
- Adela Krizova1,
- Irene Frischauf1,
- Marc Fahrner1,
- MengQi Zhang4,5,
- Linda Waldherr6,
- Tony Schmidt6,
- Isabella Derler1,
- Peter B. Stathopulos4,
- Christoph Romanin1,
- Rüdiger H. Ettrich2,7,†, and
- Rainer Schindl6,8,†
- 1Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, A-4020 Linz, Austria.
- 2Center for Nanobiology and Structural Biology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Nove Hrady CZ-373 33, Czech Republic.
- 3Schulich Dentistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada.
- 4Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada.
- 5Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.
- 6Gottfried Schatz Research Center, Medical University of Graz, A-8010 Graz, Austria.
- 7College of Biomedical Sciences, Larkin University, Miami, FL 33169, USA.
- 8BioTechMed-Graz, A-8010 Graz, Austria.
- ↵†Corresponding author. Email: rainer.schindl{at}medunigraz.at (R.S.); rettrich{at}ularkin.org (R.H.E.)
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Science Signaling 19 Nov 2019:
Vol. 12, Issue 608, eaax3194
DOI: 10.1126/scisignal.aax3194
