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Research ArticleCalcium signaling
Sequential activation of STIM1 links Ca2+ with luminal domain unfolding
- Romana Schober1,*,
- Daniel Bonhenry2,*,
- Victoria Lunz1,
- Jinhui Zhu3,4,
- Adela Krizova1,
- Irene Frischauf1,
- Marc Fahrner1,
- MengQi Zhang4,5,
- Linda Waldherr6,
- Tony Schmidt6,
- Isabella Derler1,
- Peter B. Stathopulos4,
- Christoph Romanin1,
- Rüdiger H. Ettrich2,7,†, and
- Rainer Schindl6,8,†
- 1Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, A-4020 Linz, Austria.
- 2Center for Nanobiology and Structural Biology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Nove Hrady CZ-373 33, Czech Republic.
- 3Schulich Dentistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada.
- 4Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada.
- 5Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.
- 6Gottfried Schatz Research Center, Medical University of Graz, A-8010 Graz, Austria.
- 7College of Biomedical Sciences, Larkin University, Miami, FL 33169, USA.
- 8BioTechMed-Graz, A-8010 Graz, Austria.
- ↵†Corresponding author. Email: rainer.schindl{at}medunigraz.at (R.S.); rettrich{at}ularkin.org (R.H.E.)
↵* These authors contributed equally to this work.
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Science Signaling 19 Nov 2019:
Vol. 12, Issue 608, eaax3194
DOI: 10.1126/scisignal.aax3194
Vol. 12, Issue 608, eaax3194
DOI: 10.1126/scisignal.aax3194
Romana Schober
Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, A-4020 Linz, Austria.
Daniel Bonhenry
Center for Nanobiology and Structural Biology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Nove Hrady CZ-373 33, Czech Republic.
Victoria Lunz
Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, A-4020 Linz, Austria.
Jinhui Zhu
Schulich Dentistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada.Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada.
Adela Krizova
Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, A-4020 Linz, Austria.
Irene Frischauf
Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, A-4020 Linz, Austria.
Marc Fahrner
Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, A-4020 Linz, Austria.
MengQi Zhang
Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada.Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.
Linda Waldherr
Gottfried Schatz Research Center, Medical University of Graz, A-8010 Graz, Austria.
Tony Schmidt
Gottfried Schatz Research Center, Medical University of Graz, A-8010 Graz, Austria.
Isabella Derler
Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, A-4020 Linz, Austria.
Peter B. Stathopulos
Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada.
Christoph Romanin
Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, A-4020 Linz, Austria.
Rüdiger H. Ettrich
Center for Nanobiology and Structural Biology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Nove Hrady CZ-373 33, Czech Republic.College of Biomedical Sciences, Larkin University, Miami, FL 33169, USA.
Rainer Schindl
Gottfried Schatz Research Center, Medical University of Graz, A-8010 Graz, Austria.BioTechMed-Graz, A-8010 Graz, Austria.
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