Sequential activation of STIM1 links Ca2+ with luminal domain unfolding

Romana Schober; Daniel Bonhenry; Victoria Lunz; Jinhui Zhu; Adela Krizova; Irene Frischauf; Marc Fahrner; MengQi Zhang; Linda Waldherr; Tony Schmidt; Isabella Derler; Peter B. Stathopulos; Christoph Romanin; Rüdiger H. Ettrich; Rainer Schindl

doi:10.1126/scisignal.aax3194

Research ArticleCalcium signaling

Sequential activation of STIM1 links Ca²⁺ with luminal domain unfolding

View ORCID ProfileRomana Schober¹,*,
View ORCID ProfileDaniel Bonhenry ²,*,
View ORCID ProfileVictoria Lunz¹,
View ORCID ProfileJinhui Zhu³,⁴,
View ORCID ProfileAdela Krizova¹,
View ORCID ProfileIrene Frischauf ¹,
Marc Fahrner ¹,
View ORCID ProfileMengQi Zhang⁴,⁵,
View ORCID ProfileLinda Waldherr⁶,
View ORCID ProfileTony Schmidt⁶,
View ORCID ProfileIsabella Derler ¹,
Peter B. Stathopulos ⁴,
View ORCID ProfileChristoph Romanin ¹,
View ORCID ProfileRüdiger H. Ettrich ²,⁷,†, and
View ORCID ProfileRainer Schindl ⁶,⁸,†

¹Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, A-4020 Linz, Austria.
²Center for Nanobiology and Structural Biology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Nove Hrady CZ-373 33, Czech Republic.
³Schulich Dentistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada.
⁴Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada.
⁵Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.
⁶Gottfried Schatz Research Center, Medical University of Graz, A-8010 Graz, Austria.
⁷College of Biomedical Sciences, Larkin University, Miami, FL 33169, USA.
⁸BioTechMed-Graz, A-8010 Graz, Austria.

↵†Corresponding author. Email: rainer.schindl{at}medunigraz.at (R.S.); rettrich{at}ularkin.org (R.H.E.)

↵* These authors contributed equally to this work.

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Science Signaling 19 Nov 2019:
Vol. 12, Issue 608, eaax3194
DOI: 10.1126/scisignal.aax3194

Romana Schober

1Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, A-4020 Linz, Austria.

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Daniel Bonhenry

2Center for Nanobiology and Structural Biology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Nove Hrady CZ-373 33, Czech Republic.

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Victoria Lunz

1Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, A-4020 Linz, Austria.

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Jinhui Zhu

3Schulich Dentistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada.

4Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada.

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Adela Krizova

1Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, A-4020 Linz, Austria.

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Irene Frischauf

1Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, A-4020 Linz, Austria.

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Marc Fahrner

1Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, A-4020 Linz, Austria.

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MengQi Zhang

4Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada.

5Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.

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Linda Waldherr

6Gottfried Schatz Research Center, Medical University of Graz, A-8010 Graz, Austria.

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Tony Schmidt

6Gottfried Schatz Research Center, Medical University of Graz, A-8010 Graz, Austria.

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Isabella Derler

1Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, A-4020 Linz, Austria.

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Peter B. Stathopulos

4Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada.

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Christoph Romanin

1Institute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, A-4020 Linz, Austria.

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Rüdiger H. Ettrich

2Center for Nanobiology and Structural Biology, Institute of Microbiology, Academy of Sciences of the Czech Republic, Nove Hrady CZ-373 33, Czech Republic.

7College of Biomedical Sciences, Larkin University, Miami, FL 33169, USA.

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For correspondence: rainer.schindl@medunigraz.at rettrich@ularkin.org

Rainer Schindl

6Gottfried Schatz Research Center, Medical University of Graz, A-8010 Graz, Austria.

8BioTechMed-Graz, A-8010 Graz, Austria.

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For correspondence: rainer.schindl@medunigraz.at rettrich@ularkin.org

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