Thiol-based direct threat sensing by the stress-activated protein kinase Hog1

Angel Guerra-Moreno; Miguel A. Prado; Jessie Ang; Helena M. Schnell; Yagmur Micoogullari; Joao A. Paulo; Daniel Finley; Steven P. Gygi; John Hanna

doi:10.1126/scisignal.aaw4956

Research ArticleBiochemistry

Thiol-based direct threat sensing by the stress-activated protein kinase Hog1

Angel Guerra-Moreno¹,
Miguel A. Prado²,*,
Jessie Ang¹,*,
Helena M. Schnell¹,
Yagmur Micoogullari¹,
Joao A. Paulo ²,
Daniel Finley ²,
Steven P. Gygi ², and
John Hanna ¹,†

¹Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA.
²Department of Cell Biology, Harvard Medical School, Boston, MA, USA.

↵†Corresponding author. Email: jwhanna{at}bwh.harvard.edu

↵* These authors contributed equally to this work.

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Science Signaling 26 Nov 2019:
Vol. 12, Issue 609, eaaw4956
DOI: 10.1126/scisignal.aaw4956

Angel Guerra-Moreno

Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA.

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Miguel A. Prado

Department of Cell Biology, Harvard Medical School, Boston, MA, USA.

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Jessie Ang

Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA.

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Helena M. Schnell

Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA.

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Yagmur Micoogullari

Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA.

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Joao A. Paulo

Department of Cell Biology, Harvard Medical School, Boston, MA, USA.

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Daniel Finley

Department of Cell Biology, Harvard Medical School, Boston, MA, USA.

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Steven P. Gygi

Department of Cell Biology, Harvard Medical School, Boston, MA, USA.

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John Hanna

Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA.

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For correspondence: jwhanna@bwh.harvard.edu

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vol. 12 no. 609

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https://doi.org/10.1126/scisignal.aaw4956

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Received December 27, 2018
Resubmitted May 16, 2019
Accepted November 4, 2019
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Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works http://www.sciencemag.org/about/science-licenses-journal-article-reuseThis is an article distributed under the terms of the Science Journals Default License.

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Thiol-based direct threat sensing by the stress-activated protein kinase Hog1

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