Research ResourceBiochemistry

The human secretome

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Science Signaling  26 Nov 2019:
Vol. 12, Issue 609, eaaz0274
DOI: 10.1126/scisignal.aaz0274

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Secrets of secreted proteins

Although proteins that are actively secreted from cells constitute a large proportion of the targets of pharmaceutical drugs, we lack a complete understanding of the size and composition of this group of proteins, collectively referred to as the human “secretome.” Uhlén et al. analyzed the genes of the Human Protein Atlas that encode proteins that are predicted to be secreted and combined this with data derived from antibody- and mass spectrometry–based analyses of the relative abundances, sites of origin, and final locations of proteins within the body. Their analysis suggests that many proteins that were thought to be secreted are retained intracellularly, and that another group of secreted proteins are retained locally rather than being released into the blood. These data serve as a resource for future research on this important class of proteins.

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