Contents
03 December 2019
Vol 12, Issue 610
Vol 12, Issue 610
Research Articles
- Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis
β Cell proliferation in response to insulin resistance requires hypusination of an mRNA translation factor.
- The interaction of ceramide 1-phosphate with group IVA cytosolic phospholipase A2 coordinates acute wound healing and repair
Lipid-regulated production of eicosanoids by cPLA2α directs the behaviors of dermal fibroblasts during wound repair.
- Biased M1 receptor–positive allosteric modulators reveal role of phospholipase D in M1-dependent rodent cortical plasticity
Biased modulators show that long-term depression induced by the M1 muscarinic acetylcholine receptor requires PLD.
Editors' Choice
- The long and short of antiviral activity
Only short isoforms of the pseudoenzyme PARP13 inhibit interferon responses.
Erratum
- Erratum for the Research Article: “HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species” by H. E. Nicholson, Z. Tariq, B. E. Housden, R. B. Jennings, L. A. Stransky, N. Perrimon, S. Signoretti, W. G. Kaelin
Two authors have been added; revised versions of the Fig. 2 legend, Fig. 6, and data file S2 have been swapped in; and text in the Results and the Materials and Methods has been updated.
About The Cover
Online Cover This week features a Research Article that shows that postnatal β cell proliferation in response to insulin resistance requires hypusination of the mRNA translation factor eIF5A. The image shows a pancreas stained for insulin (green), nuclei (blue), and apoptotic cells (pink). [Image: Levasseur et al./Science Signaling]
