Research ArticleWound Healing

The interaction of ceramide 1-phosphate with group IVA cytosolic phospholipase A2 coordinates acute wound healing and repair

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Science Signaling  03 Dec 2019:
Vol. 12, Issue 610, eaav5918
DOI: 10.1126/scisignal.aav5918

Lipids set the pace for wound repair

Wound repair proceeds through distinct phases. Hemostasis and inflammation are followed by proliferation and remodeling, during which fibroblasts infiltrate the wound, proliferate, and secrete collagen, which is remodeled as the epithelium regenerates. MacKnight et al. observed increased fibroblast infiltration, collagen deposition, and tensile strength in skin wounds of mice in which cytosolic phospholipase A2 (cPLA2α), the rate-limiting enzyme in eicosanoid biosynthesis, could not be activated by the sphingolipid ceramide 1-phosphate (C1P). Wound tissue and dermal fibroblasts from these mice showed reduced proinflammatory prostaglandin production and increased 5-HETE, which promoted fibroblast migration and collagen deposition. These findings suggest that C1P promotes the inflammatory phase of wound repair and inhibits the proliferation and remodeling stages and show that cPLA2α-dependent eicosanoid production fine-tunes the behaviors of dermal fibroblasts during wound repair.

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