Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis

Esther M. Levasseur; Kentaro Yamada; Annie R. Piñeros; Wenting Wu; Farooq Syed; Kara S. Orr; Emily Anderson-Baucum; Teresa L. Mastracci; Bernhard Maier; Amber L. Mosley; Yunlong Liu; Ernesto Bernal-Mizrachi; Laura C. Alonso; Donald Scott; Adolfo Garcia-Ocaña; Sarah A. Tersey; Raghavendra G. Mirmira

doi:10.1126/scisignal.aax0715

Research ArticlePhysiology

Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis

View ORCID ProfileEsther M. Levasseur ¹,²,
Kentaro Yamada¹,³,*,
View ORCID ProfileAnnie R. Piñeros¹,³,*,
View ORCID ProfileWenting Wu¹,⁴,
View ORCID ProfileFarooq Syed¹,³,
View ORCID ProfileKara S. Orr¹,³,
View ORCID ProfileEmily Anderson-Baucum⁵,
View ORCID ProfileTeresa L. Mastracci²,⁵,
View ORCID ProfileBernhard Maier⁶,
View ORCID ProfileAmber L. Mosley²,
View ORCID ProfileYunlong Liu⁴,
View ORCID ProfileErnesto Bernal-Mizrachi⁷,
Laura C. Alonso⁸,†,
View ORCID ProfileDonald Scott⁹,
View ORCID ProfileAdolfo Garcia-Ocaña ⁹,
View ORCID ProfileSarah A. Tersey¹,³,‡, and
View ORCID ProfileRaghavendra G. Mirmira ¹,²,³,⁶,‡,§

¹Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
²Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
³Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
⁴Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
⁵Indiana Biosciences Research Institute, Indianapolis, IN 46202, USA.
⁶Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
⁷Department of Medicine, University of Miami, Miami, FL 33146, USA.
⁸Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA.
⁹Diabetes, Obesity, and Metabolism Institute and the Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

↵§Corresponding author. Email: mirmira{at}uchicago.edu

↵* These authors contributed equally to this work.
↵† Present address: Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
↵‡ Present address: Kovler Diabetes Center and Department of Medicine, University of Chicago, Chicago, IL 60637, USA.

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Science Signaling 03 Dec 2019:
Vol. 12, Issue 610, eaax0715
DOI: 10.1126/scisignal.aax0715

Esther M. Levasseur

1Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

2Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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Kentaro Yamada

1Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

3Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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Annie R. Piñeros

1Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

3Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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Wenting Wu

1Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

4Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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Farooq Syed

1Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

3Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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Kara S. Orr

1Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

3Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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Emily Anderson-Baucum

5Indiana Biosciences Research Institute, Indianapolis, IN 46202, USA.

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Teresa L. Mastracci

2Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

5Indiana Biosciences Research Institute, Indianapolis, IN 46202, USA.

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Bernhard Maier

6Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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Amber L. Mosley

2Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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Yunlong Liu

4Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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Ernesto Bernal-Mizrachi

7Department of Medicine, University of Miami, Miami, FL 33146, USA.

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Laura C. Alonso

8Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA.

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Donald Scott

9Diabetes, Obesity, and Metabolism Institute and the Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

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Adolfo Garcia-Ocaña

9Diabetes, Obesity, and Metabolism Institute and the Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

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Sarah A. Tersey

1Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

3Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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Raghavendra G. Mirmira

1Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

2Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

3Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

6Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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For correspondence: mirmira@uchicago.edu

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vol. 12 no. 610

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https://doi.org/10.1126/scisignal.aax0715

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Received February 26, 2019
Accepted November 13, 2019
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Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works http://www.sciencemag.org/about/science-licenses-journal-article-reuseThis is an article distributed under the terms of the Science Journals Default License.

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Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis

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