Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis

Esther M. Levasseur; Kentaro Yamada; Annie R. Piñeros; Wenting Wu; Farooq Syed; Kara S. Orr; Emily Anderson-Baucum; Teresa L. Mastracci; Bernhard Maier; Amber L. Mosley; Yunlong Liu; Ernesto Bernal-Mizrachi; Laura C. Alonso; Donald Scott; Adolfo Garcia-Ocaña; Sarah A. Tersey; Raghavendra G. Mirmira

doi:10.1126/scisignal.aax0715

Research ArticlePhysiology

Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis

Esther M. Levasseur ¹,²,
Kentaro Yamada¹,³,*,
Annie R. Piñeros¹,³,*,
Wenting Wu¹,⁴,
Farooq Syed¹,³,
Kara S. Orr¹,³,
Emily Anderson-Baucum⁵,
Teresa L. Mastracci²,⁵,
Bernhard Maier⁶,
Amber L. Mosley²,
Yunlong Liu⁴,
Ernesto Bernal-Mizrachi⁷,
Laura C. Alonso⁸,†,
Donald Scott⁹,
Adolfo Garcia-Ocaña ⁹,
Sarah A. Tersey¹,³,‡, and
Raghavendra G. Mirmira ¹,²,³,⁶,‡,§

¹Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
²Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
³Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
⁴Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
⁵Indiana Biosciences Research Institute, Indianapolis, IN 46202, USA.
⁶Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
⁷Department of Medicine, University of Miami, Miami, FL 33146, USA.
⁸Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA.
⁹Diabetes, Obesity, and Metabolism Institute and the Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

↵§Corresponding author. Email: mirmira{at}uchicago.edu

↵* These authors contributed equally to this work.
↵† Present address: Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
↵‡ Present address: Kovler Diabetes Center and Department of Medicine, University of Chicago, Chicago, IL 60637, USA.

See allHide authors and affiliations

Science Signaling 03 Dec 2019:
Vol. 12, Issue 610, eaax0715
DOI: 10.1126/scisignal.aax0715

Esther M. Levasseur

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Esther M. Levasseur

Kentaro Yamada

Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Annie R. Piñeros

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Annie R. Piñeros

Wenting Wu

Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Wenting Wu

Farooq Syed

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Farooq Syed

Kara S. Orr

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Kara S. Orr

Emily Anderson-Baucum

Indiana Biosciences Research Institute, Indianapolis, IN 46202, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Emily Anderson-Baucum

Teresa L. Mastracci

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.Indiana Biosciences Research Institute, Indianapolis, IN 46202, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Teresa L. Mastracci

Bernhard Maier

Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Bernhard Maier

Amber L. Mosley

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Amber L. Mosley

Yunlong Liu

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Yunlong Liu

Ernesto Bernal-Mizrachi

Department of Medicine, University of Miami, Miami, FL 33146, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Ernesto Bernal-Mizrachi

Laura C. Alonso

Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Donald Scott

Diabetes, Obesity, and Metabolism Institute and the Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Donald Scott

Adolfo Garcia-Ocaña

Diabetes, Obesity, and Metabolism Institute and the Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Adolfo Garcia-Ocaña

Sarah A. Tersey

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Sarah A. Tersey

Raghavendra G. Mirmira

Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Raghavendra G. Mirmira
For correspondence: mirmira@uchicago.edu

Article
Figures & Data
Info & Metrics
eLetters
PDF

Article Information

vol. 12 no. 610

DOI:

https://doi.org/10.1126/scisignal.aax0715

PubMed:

Published By:

Print ISSN:

Online ISSN:

History:

Received February 26, 2019
Accepted November 13, 2019
.

Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works http://www.sciencemag.org/about/science-licenses-journal-article-reuseThis is an article distributed under the terms of the Science Journals Default License.

Author Information

Altmetric

Article usage

Article usage: November 2019 to January 2020

	Abstract	Full	Pdf
Nov 2019	2	8	2
Dec 2019	5957	838	245
Jan 2020	176	74	30

View Full Text

Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis

Article Information

Author Information

Altmetric

Article usage

Article usage: November 2019 to January 2020

Science Signaling

Article Tools