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Research ArticlePhysiology
Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis
- View ORCID ProfileEsther M. Levasseur1,2,
- Kentaro Yamada1,3,*,
- View ORCID ProfileAnnie R. Piñeros1,3,*,
- View ORCID ProfileWenting Wu1,4,
- View ORCID ProfileFarooq Syed1,3,
- View ORCID ProfileKara S. Orr1,3,
- View ORCID ProfileEmily Anderson-Baucum5,
- View ORCID ProfileTeresa L. Mastracci2,5,
- View ORCID ProfileBernhard Maier6,
- View ORCID ProfileAmber L. Mosley2,
- View ORCID ProfileYunlong Liu4,
- View ORCID ProfileErnesto Bernal-Mizrachi7,
- Laura C. Alonso8,†,
- View ORCID ProfileDonald Scott9,
- View ORCID ProfileAdolfo Garcia-Ocaña9,
- View ORCID ProfileSarah A. Tersey1,3,‡, and
- View ORCID ProfileRaghavendra G. Mirmira1,2,3,6,‡,§
- 1Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
- 2Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
- 3Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
- 4Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
- 5Indiana Biosciences Research Institute, Indianapolis, IN 46202, USA.
- 6Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
- 7Department of Medicine, University of Miami, Miami, FL 33146, USA.
- 8Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA.
- 9Diabetes, Obesity, and Metabolism Institute and the Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
- ↵§Corresponding author. Email: mirmira{at}uchicago.edu
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Science Signaling 03 Dec 2019:
Vol. 12, Issue 610, eaax0715
DOI: 10.1126/scisignal.aax0715
Vol. 12, Issue 610, eaax0715
DOI: 10.1126/scisignal.aax0715
Esther M. Levasseur
1Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
2Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Kentaro Yamada
1Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
3Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Annie R. Piñeros
1Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
3Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Wenting Wu
1Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
4Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Farooq Syed
1Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
3Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Kara S. Orr
1Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
3Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Emily Anderson-Baucum
5Indiana Biosciences Research Institute, Indianapolis, IN 46202, USA.
Teresa L. Mastracci
2Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
5Indiana Biosciences Research Institute, Indianapolis, IN 46202, USA.
Bernhard Maier
6Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Amber L. Mosley
2Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Yunlong Liu
4Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Ernesto Bernal-Mizrachi
7Department of Medicine, University of Miami, Miami, FL 33146, USA.
Laura C. Alonso
8Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Donald Scott
9Diabetes, Obesity, and Metabolism Institute and the Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Adolfo Garcia-Ocaña
9Diabetes, Obesity, and Metabolism Institute and the Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Sarah A. Tersey
1Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
3Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Raghavendra G. Mirmira
1Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
2Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
3Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
6Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
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