Research ResourcePhysiology

Metabolic rewiring of the hypertensive kidney

See allHide authors and affiliations

Science Signaling  10 Dec 2019:
Vol. 12, Issue 611, eaax9760
DOI: 10.1126/scisignal.aax9760

You are currently viewing the editor's summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Metabolic changes under pressure

Chronic hypertension causes irreversible damage to the kidneys. Rinschen et al. performed multi-omics analyses of kidney tissue from rats that spontaneously develop hypertension on a high-salt diet. Their metabolomic analysis revealed that at early disease stages, kidney glomeruli showed various metabolic changes, such as increased lipid breakdown, depletion of branched-chain amino acids, and energy stress. Phosphoproteomic analysis uncovered the activation of the kinase AMPK and the inhibition of the kinase-containing complex mTORC1, as would be expected due to energy stress and depletion of the branched-chain amino acid leucine, respectively. Proteomic analysis demonstrated alterations in the abundance of metabolic enzymes, which correlated with the metabolic changes seen at early disease stages. These results suggest that metabolic interventions could be potentially useful in treating hypertension-induced kidney disease.

View Full Text

Stay Connected to Science Signaling